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Vaccination
Management
Disease Information
A PMWS update (Jake Waddilove)
ABOUT PMWS & PDNS
National Pork Board PMWS Fact Sheet
About PDNS (Jake Waddilive)
CEI Emerging Disease Notices: PMWS / PDNS
Conference and meetings archive
Case Histories
Yorkshire Farm, UK - Mike Muirhead - Final Update, June 2002
Mike Muirhead's case history of a Yorkshire farm with PMWS and PDNS.
 
East Anglia Farm, UK - Philip Richardson
This paper charts the course and effects of the disease on a single herd as well as highlighting the economic impact.
Photographs
Clinical signs
Photos of the clinical signs that are seen generally in pigs with PMWS and PDNS. Includes skin lesions, enlarged lymph glands, wasting and dead pigs.
 
Post mortem (1)
Photos of the signs that are seen in post-mortem samples of pigs with PMWS and PDNS. Includes interstitial pneumonia, secondary bacterial infection, enlarged lymph nodes, oedema and intra cytoplasmic inclusions
 
Post mortem (2)
More Photos of the signs that are seen in post-mortem samples of pigs with PMWS and PDNS.


PMWS Research Archives

Published Saturday, April 01, 2006: Virus Genes, Volume 32, Number 2, pp. 145-152
A Gene Similar to the Human Hyaluronan-mediated Motility Receptor (RHAMM) Gene is Upregulated During Porcine Circovirus Type 2 Infection
Bratanich, Ana; Blanchetot, Alain
Little is known on the cellular events triggered by the Porcine Circovirus type 2 (PCV2) in Porcine Multisystemic Wasting Syndrome (PMWS). The differential display reverse-transcription PCR (DDRT-PCR) was used to identify cellular target molecules in lymph node tissue that were regulated in PMWS. Comparative profile analysis of a pool of lymph node tissues from PMWS and healthy animals showed that some transcripts were up-regulated in PMWS. Bacterial recombinant clones containing up-regulated transcripts were analyzed by reverse dot blot. Clones showing enhanced hybridization when probed with cDNAs from PMWS animals were sequenced and compared to existing databases. Two of the differentially regulated transcripts displayed homology with human genes such as an RNA splicing factor and hyaluronan-mediated motility receptor (RHAMM). Clones encoding theses genes were subsequently used as probes to analyze their expression pattern in PK15 cells persistently infected with PCV2. Northern blot analyzes indicated that these transcripts were up-regulated in these cells as observed in infected lymph node tissue from PMWS cases. A role for the up-regulation of the RHAMM gene is proposed.

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