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Vaccination
Management
Disease Information
A PMWS update (Jake Waddilove)
ABOUT PMWS & PDNS
National Pork Board PMWS Fact Sheet
About PDNS (Jake Waddilive)
CEI Emerging Disease Notices: PMWS / PDNS
Conference and meetings archive
Case Histories
Yorkshire Farm, UK - Mike Muirhead - Final Update, June 2002
Mike Muirhead's case history of a Yorkshire farm with PMWS and PDNS.
 
East Anglia Farm, UK - Philip Richardson
This paper charts the course and effects of the disease on a single herd as well as highlighting the economic impact.
Photographs
Clinical signs
Photos of the clinical signs that are seen generally in pigs with PMWS and PDNS. Includes skin lesions, enlarged lymph glands, wasting and dead pigs.
 
Post mortem (1)
Photos of the signs that are seen in post-mortem samples of pigs with PMWS and PDNS. Includes interstitial pneumonia, secondary bacterial infection, enlarged lymph nodes, oedema and intra cytoplasmic inclusions
 
Post mortem (2)
More Photos of the signs that are seen in post-mortem samples of pigs with PMWS and PDNS.


PMWS Research Archives

Published Tuesday, April 01, 2008: New Zealand Veterinary Journal, Volume 56, Number 2, April 2008 , pp. 94-99(6)
Porcine dermatitis and nephropathy syndrome in New Zealand
Johnstone, A.C.; Lawton
Abstract
CASE HISTORY: An outbreak of fatal or debilitating disease characterised by wasting and cutaneous lesions that usually necessitated euthanasia, occurred over a period of 4 months in pigs 14-16 weeks of age from a commercial 'farrow-to-finish' unit in the North Island of New Zealand. During the outbreak, 67 deaths were attributed to the condition, accounting for 2-3% of total production. The outbreak preceded the diagnosis of post-weaning multisystemic wasting syndrome (PMWS) on this farm.

CLINICAL FINDINGS: Sick pigs were thin, depressed, and pyrexic, and most had multiple extensive erythematous crusting cutaneous lesions that were most prominent in the region of the hindquarters, forequarters and head. Those with cutaneous lesions affecting the hindlimbs had subcutaneous oedema and enlarged superficial inguinal lymph nodes. Diarrhoea was commonly present.

PATHOLOGICAL FINDINGS AND DIAGNOSIS: In addition to the skin lesions, the main gross pathological changes were renal petechiation and lymphadenomegaly.
The cutaneous and renal lesions resulted from necrotising and neutrophilic vasculitis, and thrombosis and infarction of adjacent tissues. Vascular lesions were variably present in the spleen, liver, lymph nodes and intestines. Renal tubules were distended by sero-haemorrhagic fluid and proteinaceous casts. Lymphoid tissue changes typical of porcine circovirus type 2 (PCV2)-associated disease included depletion of mature lymphocytes, histiocytic infiltrations and circoviral inclusion bodies. Lesions associated with PCV2 in non-lymphoid tissues included granulomatous or non-suppurative interstitial pneumonia, interstitial nephritis, gastroenteritis, and hepatitis with hepatocellular apoptosis.

DIAGNOSIS: Porcine circovirus-associated disease (PCVAD) represented by concurrent porcine dermatitis and nephropathy syndrome (PDNS) and emergent PMWS.

CLINICAL RELEVANCE: This is the first published description of PDNS and of combined PDNS and PMWS in pigs in New Zealand. In addition, the prevalence of PDNS, which is usually a sporadic disorder, was inconsistent with a diagnosis of PDNS alone.

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