ThePigSite.com
5M Retail Now Open - Win a Ipad 2Sign up for ThePigSite weekly newsletterFollow us on Twitter
PMWS & PCVD
Home PMWS News PMWS Research PMWS Forum PMWS Newsletter
PCVD.org Dansk
PCVD.org Français
PCVD.org Svenska
PCVD.org Nederlands
PCVD.org Español
PCVD.org English


This free resource is kindly supported by: If you have a information you would like is to include in this section please contact us

Vaccination
Management
Disease Information
A PMWS update (Jake Waddilove)
ABOUT PMWS & PDNS
National Pork Board PMWS Fact Sheet
About PDNS (Jake Waddilive)
CEI Emerging Disease Notices: PMWS / PDNS
Conference and meetings archive
Case Histories
Yorkshire Farm, UK - Mike Muirhead - Final Update, June 2002
Mike Muirhead's case history of a Yorkshire farm with PMWS and PDNS.
East Anglia Farm, UK - Philip Richardson
This paper charts the course and effects of the disease on a single herd as well as highlighting the economic impact.
Photographs
Clinical signs
Photos of the clinical signs that are seen generally in pigs with PMWS and PDNS. Includes skin lesions, enlarged lymph glands, wasting and dead pigs.
Post mortem (1)
Photos of the signs that are seen in post-mortem samples of pigs with PMWS and PDNS. Includes interstitial pneumonia, secondary bacterial infection, enlarged lymph nodes, oedema and intra cytoplasmic inclusions
Post mortem (2)
More Photos of the signs that are seen in post-mortem samples of pigs with PMWS and PDNS.


PMWS Research Archives

Published Friday, October 08, 2010: Virus Research
Identification of an Amino Acid Domain Encoded by the Capsid Gene of Porcine Circovirus Type 2 that Modulates Intracellular Viral Protein Distribution During Replication
Andrew K. Cheung and Justin J. Greenlee
Previous work showed that distinct amino acid motifs are encoded by the Rep, Cap and ORF3 genes of two subgroups of porcine circoviruses (PCV), PCV2a and PCV2b. At a specific location of the gene, a certain amino acid residue or sequence is preferred. Specifically, two amino acid domains located in the capsid protein, designated motif-1 (six residues located at positions 86–91) and motif-2 (four residues at positions 190-191-206-210), have been identified to associate with either PCV2a (motif-1a:TNKISI and motif-2a:SRKD) or PCV2b (motif-1b:SNPRSV and motif-2b:AGIE) preferentially. In this study, the protein distribution pattern of a PCV2a isolate and a PCV2b isolate was examined. Each virus exhibited a different viral protein pattern during replication in porcine kidney cells and the viral protein distribution pattern was associated with amino acid motif-2 but not motif-1. The results also showed that a more robust accumulation of viral proteins in the nucleus was associated with motif-2b than with motif-2a. In addition, viruses containing motif-2b replicated better than viruses containing motif-2a in porcine kidney cells.

To continue reading this article please click here

Have you published information? To add please email the details

pcvd Merial BPEX PMWS, PCVD Technical Zone home page
 
Our Sponsors
Partners