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Vaccination
Management
Disease Information
A PMWS update (Jake Waddilove)
ABOUT PMWS & PDNS
National Pork Board PMWS Fact Sheet
About PDNS (Jake Waddilive)
CEI Emerging Disease Notices: PMWS / PDNS
Conference and meetings archive
Case Histories
Yorkshire Farm, UK - Mike Muirhead - Final Update, June 2002
Mike Muirhead's case history of a Yorkshire farm with PMWS and PDNS.
East Anglia Farm, UK - Philip Richardson
This paper charts the course and effects of the disease on a single herd as well as highlighting the economic impact.
Photographs
Clinical signs
Photos of the clinical signs that are seen generally in pigs with PMWS and PDNS. Includes skin lesions, enlarged lymph glands, wasting and dead pigs.
Post mortem (1)
Photos of the signs that are seen in post-mortem samples of pigs with PMWS and PDNS. Includes interstitial pneumonia, secondary bacterial infection, enlarged lymph nodes, oedema and intra cytoplasmic inclusions
Post mortem (2)
More Photos of the signs that are seen in post-mortem samples of pigs with PMWS and PDNS.


PMWS Research Archives

Published Wednesday, January 05, 2011: Microbiology and Immunology Jan 2011
A Candidate Inactivated Chimeric Vaccine PCV1-2 Constructed Based on PCV1 and PCV2 Isolates Originated in China and the Evaluation in Conventional Pigs for its Protective Efficacy against PCV2 Infection
Liu Xujie, Wang Xiaobo, Song Yi, Fan Jing, Gao Song, Liu Xiufan
A chimeric PCV1-2 clone containing the PCV2 capsid gene cloned into the backbone of the nonpathogenic PCV1 genome was recently generated based on the PCV2 and PCV1 strains isolated in China. Furthermore, the efficacy of this available candidate inactivated vaccine was evaluated by subjecting conventional pigs to intramuscular immunization with this inactivated chimeric PCV1-2 virus followed by the challenge with wild-type PCV2 strain. By 35 days post-vaccination (DPV), all vaccinated pigs had seroconversion to antibody against PCV2 and developed high IFA titer of antibody and neutralizing antibody. By 21 days post-challenge, gross and microscopic lesions of lymph nodes and lungs in non-vaccinated but challenged pigs were significantly more severe than those found in vaccinated groups. PCV2 viral copy loads detected in tracheobronchial lymph nodes or serum samples of vaccinated pigs were very lower than those in non-vaccinated but challenged pigs (P <0.05). The results illuminated that the inactivated PCV1-2 could induce protective immunity against PCV2 infection effectively.

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