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Vaccination
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Disease Information
A PMWS update (Jake Waddilove)
ABOUT PMWS & PDNS
National Pork Board PMWS Fact Sheet
About PDNS (Jake Waddilive)
CEI Emerging Disease Notices: PMWS / PDNS
Conference and meetings archive
Case Histories
Yorkshire Farm, UK - Mike Muirhead - Final Update, June 2002
Mike Muirhead's case history of a Yorkshire farm with PMWS and PDNS.
East Anglia Farm, UK - Philip Richardson
This paper charts the course and effects of the disease on a single herd as well as highlighting the economic impact.
Photographs
Clinical signs
Photos of the clinical signs that are seen generally in pigs with PMWS and PDNS. Includes skin lesions, enlarged lymph glands, wasting and dead pigs.
Post mortem (1)
Photos of the signs that are seen in post-mortem samples of pigs with PMWS and PDNS. Includes interstitial pneumonia, secondary bacterial infection, enlarged lymph nodes, oedema and intra cytoplasmic inclusions
Post mortem (2)
More Photos of the signs that are seen in post-mortem samples of pigs with PMWS and PDNS.


PMWS Research Archives

Published Sunday, August 28, 2011: Preventive Veterinary Medicine Volume 101, Issues 1-2, 1 August 2011, Pages 79-88
Diagnostic Performance Measures of ELISA and Quantitative PCR Tests for Porcine Circovirus Type 2 Exposure using Bayesian Latent Class Analysis
Charles Haley, Bruce Wagner, Sumathy Puvanendiran, Juan Abrahante, Michael P. Murtaugh
Porcine circovirus 2 (PCV2) is believed to be a necessary but not sufficient underlying cause of porcine circovirus associated disease (PCVAD) in swine (Opriessnig et al., 2007). Since the potential threat of PCVAD is dependent on the prevalence of PCV2 in swine populations, accurate diagnostic tests are important for epidemiologic surveillance. Therefore, we evaluated the diagnostic sensitivity (Se) and specificity (Sp) of a new indirect ELISA and two quantitative PCR tests for PCV2 in a series of latent class models that used Bayesian estimation procedures. A total of 4140 samples from finisher pigs were tested for evidence of PCV2 by the ELISA and a TaqMan (TM) quantitative PCR, 995 by the ELISA and a SYBR Green (SG) dye-binding PCR, 998 by both PCRs and 993 by all three tests. Overall, the median (95% probability interval) ELISA Se and Sp was 0.85 (0.83–0.87) and 0.74 (0.68–0.79), respectively, when all three tests were analyzed together at an ELISA absorbance (optical density or OD) cutoff of >0.3. The TM PCR Se and Sp was 0.86 (0.84–0.88) and 0.94 (0.87–0.97), respectively, and the SG PCR Se and Sp was 0.83 (0.81–0.85) and 0.98 (0.94–1.00), respectively when all three tests were analyzed together at an ELISA OD cutoff of >0.3. Sensitivity analysis revealed that Sp estimates in general had less stability than Se estimates, but the SG PCRSp was the most stable. Limited conditional dependence between the two PCR tests was detected. We conclude that the ELISA had the highest diagnostic Se at an absorbance cutoff of >0.3, while the SG PCR had the highest diagnostic Sp. The prevalence levels for exposure to PCV2 in finishing swine populations across all analyses ranged from 58 to 100%.

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