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Published Saturday, December 22, 2012: Veterinary Microbiology - Available online 22 December 2012 -In Press, Accepted Manuscript
Emergence of a Novel Mutant PCV2b Variant Associated with Clinical PCVAD in Two Vaccinated Pig Farms in the U.S. Concurrently Infected with PPV2
Tanja Opriessnig, Chao-Ting Xiao, Priscilla F. Gerber, Patrick G. Halbur
Porcine circovirus (PCV) type 2b (PCV2b) emerged in North America in 2005-2006. During May of 2012, PCVAD occurred in 10-to-18-week-old pigs in two farms within a production system that routinely vaccinated against PCV2. Both farms received replacement gilts from the same multiplier. A mutant PCV2b strain not previously present in North America was identified. The strain was found to be 99.9% identical to a recently described mutant PCV2 isolate reported in China in 2010 and thought to be more virulent than classical PCV2a or PCV2b strains. It is possible that the current PCV2a-based commercial vaccines are not fully protective against this new strain. In addition, emerging porcine parvovirus type 2 (PPV2) was detected in 55% of the serum samples (73/132), perhaps implying that PPV2 could be a cofactor in cases of PCVAD.

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