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PMWS Research Archives
Published Dec 2010: Journal of Virological Methods, Volume 170, Issues 1-2, December 2010, Pages 140-146Development of SYBR Green-Based Real-Time PCR and Duplex Nested PCR Assays for Quantitation and Differential Detection of Species- or Type-Specific Porcine Torque Teno Viruses
Y.W. Huang, B.A. Dryman, K.K. Harrall, E.M. Vaughn, M.B. Roof, X.J. Meng
Porcine Torque teno virus (TTV), a single-stranded circular DNA virus, has been incriminated in swine diseases recently. Multiple infection with porcine TTV species 1 (PTTV1) and species 2 (PTTV2), each consisting of two types (PTTV1a and 1b) or subtypes...
Published Dec 2010: Acta Vet Hung. 2010 Dec 1;58(4):475-481.
Prevalence of Porcine Circoviruses in Transylvanian Wild Boars, Detected by Real-Time PCR - Short Communication.
Cadar D, Cságola A, Spinu M, Dán A, Ursu K, Lőrincz M, Tuboly T.
Porcine circoviruses (PCV) are widespread in domestic pigs worldwide and there is growing information about the presence of PCV in other suid species. Based on serological studies with sera of wild boars, it was established that PCV1 was present in these...
Published Nov 2010: Research in Veterinary Science
Singular PCV2a or PCV2b Infection Results in Apoptosis of Hepatocytes in Clinically Affected Gnotobiotic Pigs
Avanti Sinha, Shayleen Schalk, Kelly M. Lager, Chong Wang, Tanja Opriessnig
Porcine circovirus type 2 (PCV2) is clinically associated with respiratory disease, failure-to-thrive, hepatitis, and diarrhea; however, the precise pathogenesis of PCV2-associated disease and in particular its involvement in apoptosis is still controversial....
Published Nov 2010: Veterinary Microbiology
Further Comments on PCV2 Genotype Definition and Nomenclature
Martà Cortey, Alex Olvera, Llorenç Grau-Roma and Joaquim Segalés
Published Nov 2010: Veterinary Microbiology
Immunopathological Characterization of Porcine Circovirus Type 2 Infection-Associated Follicular Changes in Inguinal Lymph Nodes Using High-Throughput Tissue Microarray
Chun-Ming Lin, Chian-Ren Jeng, Shih-Hsuan Hsiao, Jen-Pei Liu, Chih-Cheng Chang, Ming-Tang Chiou, Yi-Chieh Tsai, Mi-Yuan Chia and Victor Fei Pang
The immunopathogenesis of porcine circovirus type 2 (PCV2) infection in conventional pigs is complicated by various environmental factors and individual variation and is difficult to be completely reproduced experimentally. In the present field-based...
Published Nov 2010: Veterinary Microbiology
Shedding and Infection Dynamics of Porcine Circovirus Type 2 (PCV2) after Experimental Infection
A.R. Patterson, S. Ramamoorthy, b, D.M. Madson, X.J. Meng, P.G. Halbur and T. Opriessnig
The objective of this study was to determine the amount and infectivity of porcine circovirus type 2 (PCV2) shed in nasal, oral and fecal secretions following experimental infection. Fecal, oral and nasal swabs and blood were collected at regular intervals...
Published Nov 2010: Veterinary Microbiology
Shedding and Infection Dynamics of Porcine Circovirus Type 2 (PCV2) After Natural Exposure
A.R. Patterson, D.M. Madson, P.G. Halbur and T. Opriessnig
The objective of this study was to determine the amount of porcine circovirus type 2 (PCV2) shed in nasal, oral and fecal secretions over time following natural PCV2 infection. Fecal, oral and nasal swabs and blood were collected at regular intervals...
Published Nov 2010: Journal of Comparative Pathology, Volume 143, Issue 4, November 2010, Page 326
Ocurrence of Porcine Circovirus Type 2 (PCV-2) in Cases of Antibiotic Non-responsive Diarrhoea in Pigs
A. Szczotka, J. Zmudzki, Z. Pejsak, T. Stadejek
Published Nov 2010: Journal of Comparative Pathology, Volume 143, Issue 4, November 2010, Page 329
Histopathological Changes in Swine Affected with Porcine Circovirus-2
T. Järveots, T. Saar, D. Põdersoo, I. Blank, T. Niine
Published Nov 2010: Journal of Virology, November 2010, p. 11440-11447, Vol. 84, No. 21
Cytotoxicity of ORF3 Proteins from a Nonpathogenic and a Pathogenic Porcine Circovirus
Mark Chaiyakul, Karolynn Hsu, Rkia Dardari, Frank Marshall, and Markus Czub
Porcine circovirus type 2 (PCV2) infection is associated with significant and serious swine diseases worldwide, while PCV1 appears to be a nonpathogenic virus. Previous studies demonstrated that the ORF3 protein of PCV2 (PCV2ORF3) was involved in PCV2...
Published Nov 2010: Preventive Veterinary Medicine Volume 97, Issue 2, 1 November 2010, Pages 100-106
A Cohort Study of Post-Weaning Multisystemic Wasting Syndrome and PCV2 in 178 pigs from Birth to 14 Weeks on a Single Farm in England
K.A. Woodbine, M.J. Turner, G.F. Medley, P.D. Scott, A.J. Easton, J. Slevin, J.C. Brown, L. Francis and L.E. Green
Our hypothesis was that pigs that develop post-weaning multisystemic wasting syndrome (PMWS) are detectable from an early age with signs of weight loss and other clinical and serological abnormalities. Therefore, the objective of this study was to investigate...
Published Oct 2010: Virol J. 2010; 7: 274. Published online 2010 October
Development and Validation of an ELISA using a Protein Encoded by ORF2 Antigenic Domain of Porcine Circovirus Type 2
Shi-Qi Sun, Hui-Chen Guo, De-Hui Sun, Shuang-Hui Yin, You-Jun Shang, Xue-Peng Cai, and Xiang-Tao Liu
Background The capsid protein (ORF2) is a major structural protein of porcine circovirus type 2 (PCV2). A simple and reliable diagnostic method based on ORF2 protein immunoreactivity would serve as a valuable diagnostic method for detecting serum...
Published Oct 2010: Vaccine
Novel Chimeric Porcine Circovirus (PCV) with the Capsid Gene of the Emerging PCV2b Subtype Cloned in the Genomic Backbone of the Non-Pathogenic PCV1 is Attenuated in vivo & Induces Protective & Cross-Protective Immunity against PCV2b & PC
Nathan M. Beach, Sheela Ramamoorthy, Tanja Opriessnig, Stephen Q. Wu and Xiang-Jin Meng
Porcine circovirus type-2b (PCV2b) is the primary global causative agent of porcine circovirus-associated disease (PCVAD). In this study, we first constructed a novel chimeric virus (PCV1-2b) with the PCV2b capsid gene cloned into the backbone of non-pathogenic...
Published Oct 2010: Veterinary Microbiology Volume 145, Issues 3-4, 26 October 2010, Pages 209-219
Dual Heterologous Porcine Circovirus Genogroup 2a/2b Infection Induces Severe Disease in Germ-Free Pigs
J.C.S. Harding, J.A. Ellis, K.A. McIntosh and S. Krakowka
Our primary objectives were to determine: the relative virulence of porcine circovirus (PCV) 2a and PCV2b, if heterologous infection induces severe illness, and the relative concentration of PCV2a and PCV2b in tissues of heterologously infected pigs....
Published Oct 2010: Prev Vet Med. 2010 Oct 29. [Epub ahead of print]
Assessment and Quantification of Post-Weaning Multi-Systemic Wasting Syndrome Severity at Farm Level.
Alarcon P, Velasova M, Werling D, Stärk KD, Chang YM, Nevel A, Pfeiffer DU, Wieland B.
Post-weaning multi-systemic wasting syndrome (PMWS) causes major economic losses for the English pig industry and severity of clinical signs and economic impact vary considerably between affected farms. We present here a novel approach to quantify severity...
