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PMWS Research Archives

Published Sep 2011: Virus Research - Available online 16 September 2011.
Concurrent Infections are Important for Expression of Porcine Circovirus Associated Disease
Tanja Opriessnig, Patrick G. Halbur
Porcine circovirus type 2 (PCV2) is the essential component of porcine circovirus disease (PCVD) as the disease syndrome is referred to in Europe and porcine circovirus associated disease (PCVAD) as it is referred to in North America. Singular PCV2 infection...

Published Sep 2011: Virology Journal 2011, 8:437
Genetic Characterization of Porcine Circovirus 2 found in Malaysia
Seetha Jaganathan, Ooi P Toung, Phang L Yee, Tan D Yew, Choo P Yoon and Lim B Keong
Background Porcine circovirus type 2 is the primary etiological agent associated with a group of complex multi-factorial diseases classified as Porcine Circovirus Associated Diseases (PCVAD). Sporadic cases reported in Malaysia in 2007 caused major economic...

Published Sep 2011: Infection, Genetics and Evolution - Available online 7 September 2011.
Molecular Study of Porcine Circovirus Type 2 Circulating in Portugal
Ana M. Henriques, Margarida Duarte, Teresa Fagulha, Fernanda Ramos, Sílvia C. Barros, Tiago Luís, Miguel Fevereiro
Porcine circovirus type 2 (PCV2) belongs to the genus Circovirus of the Circoviridae family and has been associated with a disease named postweaning multisystemic wasting syndrome (PMWS). In Portugal the disease caused severe problems mainly between 1995...

Published Sep 2011: Virology - Volume 419, Issue 2, 25 October 2011, Pages 57-63
Porcine Circovirus Genotype 2a (PCV2a) and Genotype 2b (PCV2b) Recombinant Mutants showed Significantly Enhanced Viral Replication and Altered Antigenicity in vitro
Longjun Guo, Yuehua Lu, Yanwu Wei, Liping Huang, Hongli Wu, Changming Liu
Two recombinant mutants of porcine circovirus type 2 (PCV2), which resulted from replacement of a genomic fragment containing the open reading frame 2 (ORF2) of genotype PCV2b with that of genotype PCV2a, were obtained initially from co-infection with...

Published Sep 2011: Veterinary Record 2011 - Published Online 2 September 2011
Linked Outbreaks and Control of Porcine Reproductive and Respiratory Syndrome and Postweaning Multisystemic Wasting Syndrome in a Pig Farm in Poland
T. Stadejek, K. Podgorska, M. Porowski, A. Jablonski and Z. Pejsak
In a newly established farrow-to-finish farm (porcine reproductive and respiratory virus [PRRSV]-free, porcine circovirus type 2 [PCV-2]-infected), reproductive failure was seen seven months after population. The conception rate dropped from 89 to 51...

Published Aug 2011: BMC Microbiology 2011, 11:188 - August
Identification of One Critical Amino Acid That Determines a Conformational Neutralizing Epitope in the Capsid Protein of Porcine Circovirus Type 2
Li P Huang, Yue H Lu, Yan W Wei, Long J Guo and Chang M Liu
Background Porcine circovirus type 2 (PCV2) is associated with post-weaning multisystemic wasting syndrome (PMWS) in pigs. Currently, there is considerable interest in the immunology of PCV2; in particular, the immunological properties of the capsid...

Published Aug 2011: Preventive Veterinary Medicine Volume 101, Issues 1-2, 1 August 2011, Pages 79-88
Diagnostic Performance Measures of ELISA and Quantitative PCR Tests for Porcine Circovirus Type 2 Exposure using Bayesian Latent Class Analysis
Charles Haley, Bruce Wagner, Sumathy Puvanendiran, Juan Abrahante, Michael P. Murtaugh
Porcine circovirus 2 (PCV2) is believed to be a necessary but not sufficient underlying cause of porcine circovirus associated disease (PCVAD) in swine (Opriessnig et al., 2007). Since the potential threat of PCVAD is dependent on the prevalence of PCV2...

Published Aug 2011: Journal of Comparative Pathology - Volume 145, Issues 2-3, August-October 2011, Pages 261-270
Experimental Reproduction of Porcine Circovirus Type 2 (PCV2)-Associated Enteritis in Pigs Infected with PCV2 Alone or Concurrently with Lawsonia intracellularis or Salmonella typhimurium
T. Opriessnig, D.M. Madson, M. Roof, S.M. Layton, S. Ramamoorthy, X.J. Meng, P.G. Halbur
Porcine circovirus (PCV)-associated disease (PCVAD) has emerged to become one of the most economically important pig diseases globally. One of the less commonly recognized clinical manifestations of PCVAD is PCV2 type 2 (PCV2)-associated enteritis in...

Published Aug 2011: Vaccine - Available online 9 August 2011.
Investigations of Porcine Circovirus Type 1 (PCV1) in Vaccine-Related and Other Cell Lines
Hailun Ma, Syed Shaheduzzaman, Dhanya K. Willliams, Yamei Gao, Arifa S. Khan
Porcine circovirus type 1 (PCV1) is highly prevalent in swine and was recently reported in U.S. licensed rotavirus vaccines. Since animal-derived raw materials, such as cells, trypsin, and serum, can be a major source of introducing virus contamination...

Published Aug 2011: Vet Microbiol. Volume 151, Issues 3-4, 5 August 2011, Pages 245-254
Phylogenetic Networks to Study the Origin and Evolution of Porcine Circovirus Type 2 (PCV2) in Cuba.
Pérez LJ, de Arce HD, Cortey M, Domínguez P, Percedo MI, Perera CL, Tarradas J, Frías MT, Segalés J, Ganges L, Núñez JI.
Porcine circovirus type 2 (PCV2) is the essential etiological infectious agent of postweaning multisystemic wasting syndrome (PMWS), which is considered one of the most economically important swine diseases worldwide. In this study, a comparison between...

Published Aug 2011: The Journal of Virology, August 2011,p. 7856-7862, Vol. 85, No. 15
The 2.3-Angstrom Structure of Porcine Circovirus 2
Reza Khayat, Nicholas Brunn, Jeffrey A. Speir, John M. Hardham, Robert G. Ankenbauer, Anette Schneemann, and John E. Johnson
Porcine circovirus 2 (PCV2) is a T=1 nonenveloped icosahedral virus that has had severe impact on the swine industry. Here we report the crystal structure of an N-terminally truncated PCV2 virus-like particle at 2.3-Å resolution, and the cryo-electron...

Published Aug 2011: Research in Veterinary Science - Volume 93, Issue 1, August 2012, Pages 310–312
Fatal Bronchopneumonia in a Metastrongylus Elongatus and Porcine Circovirus Type 2 Co-Infected Pig
G. Marruchella, B. Paoletti, R. Speranza, G. Di Guardo
Porcine circovirus type 2 (PCV2) infection is distributed worldwide and PCV2-associated disease (PCVAD) is considered among the most economically relevant ones to the global swine industry. PCV2 is known to play a causal role in the porcine respiratory...

Published Jul 2011: Theriogenology Volume 76, Issue 2, 15 July 2011, Pages 351-360
Porcine Circovirus Type 2 (PCV2) Vaccination is Effective in Reducing Disease and PCV2 Shedding in Semen of Boars Concurrently Infected with PCV2 and Mycoplasma hyopneumoniae
T. Opriessnig, D.M. Madson, S. Schalk, S. Brockmeier, H.G. Shen, N.M. Beach, X.J. Meng, R.B. Baker, E.L. Zanella, P.G. Halbur
The objectives were to determine whether the amount of porcine circovirus type 2 (PCV2) shed in semen increased in boars experimentally coinfected with Mycoplasma hyopneumoniae (MHYO), and whether PCV2 vaccination of boars prior to PCV2 exposure reduced...

Published Jul 2011: The Veterinary Journal Volume 189, Issue 1, July 2011, Pages 58-62
Comparative Efficacy of Three Commercial PCV2 Vaccines in Conventionally Reared Pigs
KwangSoo Lyoo, HanSoo Joo, Brian Caldwell, HyeunBum Kim, Peter R. Davies, Jerry Torrison
The aim of this study was to compare the efficacy of three commercial porcine circovirus type 2 (PCV2) vaccines. Twenty 3-week old pigs were injected with one of three different vaccines, A, B, C, or were unvaccinated controls. Pigs in group A were...

Published Jul 2011: Prev Vet Med. 2011 Sep 1;101(3-4):182-91. Epub 2011 Jul 13.
Farm Level Risk Factors Associated With Severity of Post-Weaning Multi-Systemic Wasting Syndrome.
Alarcon P, Velasova M, Mastin A, Nevel A, Stärk KD, Wieland B.
A cross-sectional study involving 147 pig farms across England was conducted in 2008-2009. Farm severity of post-weaning multi-systemic wasting syndrome (PMWS) was estimated through the use of an algorithm that combined data on post-weaning mortality,...

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