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PMWS Research Archives
Published Feb 2006: Veterinary Research Communications, Volume 30, Number 2,Serological Investigation and Genomic Characterization of PCV2 Isolates from Different Geographic Regions of Zhejiang Province in China
Zhou JY, Chen QX, Ye JX, Shen HG, Chen TF, Shang SB.
Sera collected from 46 swine farms in Zhejiang province were evaluated for the presence of antibodies to PCV2 using an indirect-fluorescent antibody procedure. In addition PCV2 isolated from superficial inguinal lymph node samples collected from 40-to...
Published Jan 2006: BMC Veterinary Research, 2:6
Correlation between the presence of neutralizing antibodies against porcine circovirus 2 (PCV2) and protection against replication of the virus and development of PCV2-associated disease
Peter Meerts, Gerald Misinzo, David Lefebvre, Jens Nielsen, Anette Bøtner, Charlotte S Kristensen and Hans J Nauwynck
Background: In a previous study, it was demonstrated that high replication of Porcine circovirus 2 (PCV2) in a gnotobiotic pig was correlated with the absence of PCV2-neutralizing antibodies. The aim of the present study was to investigate if this correlation...
Published Jan 2006: Virology -
Inhibition of porcine circovirus type 2 replication in mice by RNA interference.
Liu J, Chen I, Chua H, Du Q, Kwang J.
Porcine circovirus type 2 (PCV2) is the primary causative agent of an emerging swine disease, postweaning multisystemic wasting syndrome (PMWS) for which no antiviral treatment is available. To exploit the possibility of using RNA interference (RNAi)...
Published Jan 2006: Vet Journal 171(1):166-8. -
Identification of porcine circovirus type 2 in retrospective cases of pigs naturally infected with porcine epidemic diarrhoea virus.
Jung K, Ha Y, Ha SK, Kim J, Choi C, Park HK, Kim SH, Chae C.
The identification of porcine circovirus type 2 (PCV2) was studied in fresh intestinal tissues by polymerase chain reaction (PCR) and in formalin-fixed, paraffin-wax-embedded intestinal tissues by in situ hybridisation. The tissues came from pigs naturally...
Published Jan 2006: J Comp Pathol
Cardiovascular lesions in pigs naturally or experimentally infected with porcine circovirus type 2.
Opriessnig T, Janke BH, Halbur PG.
Abundant intracytoplasmic porcine circovirus type 2 (PCV2) was associated with myocardiocyte swelling or necrosis, or myocardial fibrosis (or both) in three naturally infected pigs aged 4-7 weeks from three different farms. One 6 week old pig from a fourth...
Published Dec 2005: Porc Magazine, December 2005, N°394, 60-63
La MAP et son virus: le changement dans la continuité [PMWS and its virus: change and continuity].
BERGER F
A PMWS roundtable organized by Merial is the occasion to draw up the main features of this still disconcerting disease. Pallor, wasting and enlarged lymph nodes are the main clinical signs, together with pneumonia and gastric ulcers. Three elements are...
Published Dec 2005: Viral Immunology, Volume 18, N°2, 333-341
Correlation between type of adaptive immune response against porcine circovirus type 2 and level of virus replication.
MEERTS P, VAN GUCHT S, COX E, VANDEBOSCH A, NAUWYNCK HJ
The aim of this study was to determine which immunological mechanisms lead to the replication of porcine circovirus type 2 (PCV2) in pigs. Sixteen gnotobiotic piglets were inoculated with PCV2 when they were 19-day old. Cyclosporin A (CysA) was then administered...
Published Dec 2005: Res Vet Sci -
Pathological and aetiological studies of multifocal interstitial nephritis in wasted pigs at slaughter.
Martinez J, Segales J, Aduriz G, Atxaerandio R, Jaro P, Ortega J, Peris B, Corpa JM.
Multifocal interstitial nephritis in pigs has been associated with several infectious agents. The objective of the present study was to investigate several different potential infectious agents associated with "white-spotted" kidneys in pigs suffering...
Published Nov 2005: Arch Virol.
Genetic characterization of type 2 porcine circoviruses detected in Hungarian wild boars.
Csagola A, Kecskemeti S, Kardos G, Kiss I, Tuboly T.
Porcine circoviruses (PCV) are present in pigs worldwide; they are grouped into two types: PCV1 comprising non-pathogenic viruses and PCV2 responsible for several clinical manifestations. Both types are frequently detected in domestic pigs, the prevalence...
Published Nov 2005: Xenotransplantation Volume 12 Issue 6 Page 465 -
Ultrastructural alterations in human blood leukocytes induced by porcine circovirus type 1 infection
Gabriel Arteaga-Troncoso, Fernando Guerra-Infante, Luz Maria Rosales-Montaño, Francisco Javier Díaz-García and Saúl Flores-Medina
Background: Swine infectious pathogens, especially viruses, represent a potential public health risk associated with the use of pig tissues for xenotransplantation in humans. We hypothesized that porcine circovirus type I (PCV-1) may infect human...
Published Nov 2005: J Interferon Cytokine Res. - 25(11):684-93
Enhancement of porcine circovirus 2 replication in porcine cell lines by IFN-gamma before and after treatment and by IFN-alpha after treatment.
Meerts P, Misinzo G, Nauwynck HJ.
Stimulation of the porcine immune system causes increased replication of porcine circovirus 2 (PCV2) in vivo. In the present study, we investigated whether various cytokines (interleukin-1 [IL-1], IL-6, IL-10, tumor necrosis factor-alpha [TNF-alpha],...
Published Nov 2005: Vet Immunol Immunopathol. 24 -
Immunopathological effects of porcine circovirus type 2 (PCV2) on swine alveolar macrophages by in vitro inoculation.
Chang HW, Jeng CR, Lin TL, Liu JJ, Chiou MT, Tsai YC, Chia MY, Jan TR, Pang VF.
Porcine circovirus type 2 (PCV2) is the primary causative agent of postweaning multisystemic wasting syndrome (PMWS), a multifactorial disease, in pigs. Monocyte/macrophage lineage cells, including alveolar macrophages (AMs), are the major target cells...
Published Nov 2005: Clin Diagn Lab Immunol. - 12(11):1347-51. -
Effects of porcine circovirus type 2 (PCV2) maternal antibodies on experimental infection of piglets with PCV2.
McKeown NE, Opriessnig T, Thomas P, Guenette DK, Elvinger F, Fenaux M, Halbur PG, Meng XJ.
To determine the effects of porcine circovirus type 2 (PCV2) maternal antibodies on and response to experimental PCV2 infection, 24 piglets were divided into four groups on the basis of the enzyme-linked immunosorbent assay titers of PCV2 maternal antibodies:...
Published Nov 2005: Veterinary Microbiology, In Press, Corrected Proof,
Quantification of porcine circovirus type 2 (PCV2) DNA in serum and tonsillar, nasal, tracheo-bronchial, urinary and faecal swabs of pigs with and without postweaning multisystemic wasting syndrome (PMWS)
J. Segalés, M. Calsamiglia, A. Olvera, M. Sibila, L. Badiella and M. Domingo
The present study focused on PCV2 quantification by TaqMan PCR in nasal (n = 99), tonsillar (n = 108), tracheo-bronchial (n = 72), urinary (n = 91) and faecal (n = 42) swabs, as well as in serum (n = 57), from...
Published Nov 2005: Pig Journal Volume: 56 -
Post-weaning Multisystemic Wasting Syndrome (PMWS) in Denmark - The situation to date
P. Baekbo
Post-wasting Multisystemic Wasting Syndrome (PMWS) was first diagnosed in Denmark in 2000. In April 2005, Denmark had 541 confirmed cases of PMWS. This corresponds to a prevalence of approximately 10 per cent of all sow herds. However, the estimated...
