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PMWS Research Archives
Published Oct 2010: Virology Journal 2010, 7:286Molecular Characterization of Porcine Circovirus 2 Isolated from Diseased Pigs Co-Infected with Porcine Reproductive and Respiratory Syndrome Virus
Jianzhong Yi and Chengqian Liu
In this study, we isolated a porcine circovirus 2 (PCV2) strain from piglets co-infected with porcine reproductive and respiratory syndrome virus (PRRSV). The complete genome of this strain was sequenced, phylogenetic and polymorphic analyses were carried...
Published Oct 2010: Preventive Veterinary Medicine
High Prevalence of Porcine Circovirus Viremia in Newborn Piglets In Five Clinically Normal Swine Breeding Herds in North America
Huigang Shen, Chong Wang, Darin M. Madson and Tanja Opriessnig
Porcine circovirus type 2 (PCV2) can be vertically transmitted resulting in fetal infection with or without clinical signs and lesions. The primary objective of this study was to assess the prevalence of intrauterine PCV2 infection in clinically normal...
Published Oct 2010: Virol J. 2010; 7: 273. Published online 2010 October 19
Porcine Circovirus Type 2 (PCV2): Genetic Variation and Newly Emerging Genotypes in China
Long J Guo, Yue H Lu, Yan W Wei, Li P Huang, and Chang M Liu
Background Porcine circovirus type 2 (PCV2), the causative agent of postweaning multisystemic wasting syndrome (PMWS), is a serious economic problem for the swine industry in China. In this study, we investigated the genetic variation of PCV2...
Published Oct 2010: Livestock Science
The Performance Response of Pigs of Different Wean Weights to ‘High’ or ‘Low’ Input Dietary Regimes Between Weaning and 20 Weeks of Age
E. Magowan, M.E.E. Ball, K.J. McCracken, V.E. Beattie, R. Bradford, M.J. Robinson, M. Scott, F.J. Gordon and C.S. Mayne
In a 3 × 2 × 2 factorial design, this study aimed to compare the lifetime performance of light (average of 7.1 kg), medium (average of 8.9 kg) or heavy (average of 10.4 kg) wean weight pigs when offered either a high (12 kg/pig) or low (6 kg/pig) allowance...
Published Oct 2010: Virus Research
Identification of an Amino Acid Domain Encoded by the Capsid Gene of Porcine Circovirus Type 2 that Modulates Intracellular Viral Protein Distribution During Replication
Andrew K. Cheung and Justin J. Greenlee
Previous work showed that distinct amino acid motifs are encoded by the Rep, Cap and ORF3 genes of two subgroups of porcine circoviruses (PCV), PCV2a and PCV2b. At a specific location of the gene, a certain amino acid residue or sequence is preferred....
Published Oct 2010: J. Gen. Virol., Oct 2010; 91: 2585 - 2591.
Genomic Expression Profiling in Lymph Nodes with Lymphoid Depletion from Porcine Circovirus 2-Infected Pigs
Garam Lee, Dongun Han, Jae-Young Song, Yong-Soon Lee, Kyung-Sun Kang, and Sorah Yoon
Porcine circovirus type 2 (PCV2) is the main causative agent of porcine circovirus-associated disease, such as post-weaning multisystemic wasting syndrome, which involves lymphocyte depletion. However, little is known about the molecular mechanisms of...
Published Oct 2010: Veterinary Microbiology Volume 145, Issues 3-4, 26 October 2010, Pages 209-219
Dual Heterologous Porcine Circovirus Genogroup 2a/2b Infection Induces Severe Disease in Germ-Free Pigs
Harding, J.C.S., Ellis, J.A. , McIntosh, K.A., Krakowka, S
Our primary objectives were to determine: the relative virulence of porcine circovirus (PCV) 2a and PCV2b, if heterologous infection induces severe illness, and the relative concentration of PCV2a and PCV2b in tissues of heterologously infected pigs....
Published Oct 2010: Veterinary Immunology and Immunopathology, 137 (3-4), p.226, Oct 2010
Porcine Circovirus Type 2 (PCV2) Cap and Rep Proteins are Involved in the Development of Cell-Mediated Immunity upon PCV2 Infection
Fort, Maria / Sibila, Marina / NofrarÃas, Miquel / Pérez-MartÃn, Eva / Olvera, Alex / Mateu, Enric / Segalés, Joaquim
The aim of the present study was to investigate the role of the capside (Cap) and replicase (Rep) proteins of Porcine circovirus type 2 (PCV2) as well as the whole PCV2 (both PCV2a and PCV2b genotypes) in the induction of cell-mediated immunity upon infection....
Published Oct 2010: Research in Veterinary Science, In Press, Corrected Proof,Oct 2010
Ear Necrosis Reduction in Pigs after Vaccination against PCV2
Pejsak, Z. / Markowska-Daniel, I. / Pomorska-Mól, M. / Porowski, M. / Kołacz, R
The influence of sows vaccination against PCV2 on the prevalence of ear necrosis syndrome (ENS) reduction among weaners was analyzed using 12,931 piglets from 45 consecutive batches, born to both, vaccinated and non-vaccinated sows. The results were statistically...
Published Oct 2010: Antiviral Research, 88 (1), p.19, Oct 2010
Neutralization of Infectivity of Porcine Circovirus Type 2 (PCV2) by Capsid-Binding 2′F-RNA Aptamers
Yoon, Sorah / Lee, Garam / Han, Dongun / Song, Jae-Young / Kang, Kyung-Sun / Lee, Yong-Soon
Porcine circovirus type 2 (PCV2) is the main causative agent of porcine circovirus-associated diseases (PCVD), which is responsible for economic losses in the swine industry. The capsid protein of PCV2 has important role for virus neutralization that...
Published Oct 2010: Res Vet Sci. 2010 Oct;89(2):301-5. Epub 2010 Mar 29.
Genetic Characterization and Phylogenetic Analysis of Porcine Circovirus Type 2 Strains Present in Cuban Swine Herds.
Pérez LJ, DÃaz de Arce H, FrÃas MT.
Porcine circovirus type 2 (PCV2) is the essential infectious agent of postweaning multisystemic wasting syndrome (PMWS) considered as one of the most important swine diseases worldwide. One of the main risk factors reported for the development of PMWS...
Published Sep 2010: Vet Microbiol. 2010 Sep 28;145(1-2):62-8. Epub 2010 Mar 27.
Pathologic and Virologic findings in Mid-Gestational Porcine Foetuses after Experimental Inoculation with PCV2a or PCV2b.
Saha D, Lefebvre DJ, Van Doorsselaere J, Atanasova K, Barbé F, Geldhof M, Karniychuk UU, Nauwynck HJ.
Two major genotypes of porcine circovirus type 2 (PCV2) have been described: PCV2a and PCV2b. Previous studies mainly used PCV2a to experimentally reproduce reproductive failure in sows. This study aims to determine the clinical and virological outcome...
Published Sep 2010: Biomed Biotechnol. 2011; 2011: 245728. Published online 2010 September 27
Bronchiolitis Obliterans Organizing Pneumonia in Swine Associated with Porcine Circovirus Type 2 Infection
Ching-Chang Cheng, Yen-Feng Lee, Nai-Nu Lin, Chieh-Liang Wu, Kwong-Chung Tung, and Yung-Tsung Chiu
Bronchiolitis obliterans organizing pneumonia (BOOP) is a chronic respiratory disease. Although the pathogenesis of BOOP is still incompletely understood, BOOP is responsive to steroids and has a good prognosis. In our five pigs with chronic postweaning...
Published Sep 2010: J Vet Sci. 2010 Sep;11(3):177-83.
Distribution and Characterization of IL-10-Secreting Cells in Lymphoid Tissues of PCV2-Infected Pigs.
Doster AR, Subramaniam S, Yhee JY, Kwon BJ, Yu CH, Kwon SY, Osorio FA, Sur JH.
Distribution and characterization of interlukin-10 (IL-10)-secreting cells in lymphoid tissues of pigs naturally infected with porcine circovirus type 2 (PCV2) were evaluated in accordance with PCV2 antigen detection. After screening a total of 56 pigs...
Published Sep 2010: Vet Res. 2010 9-10;41(5):60. Epub 2010 May 24.
Porcine Circovirus Type 2 (PCV2) Induces Cell Proliferation, Fusion, and Chemokine Expression in Swine Monocytic Cells In Vitro.
Tsai YC, Jeng CR, Hsiao SH, Chang HW, Liu JJ, Chang CC, Lin CM, Chia MY, Pang VF.
Granulomatous lymphadenitis is one of the pathognomonic lesions in post-weaning multisystemic wasting syndrome (PMWS)-affected pigs. This unique lesion has not been reported in direct association with viral infection in pigs. The objective of the present...
