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PMWS Research Archives

Published Jul 2011: Virology Journal 2011, 8:341
Functional Exchangeability of the Nuclear Localization Signal (NLS) of Capsid Protein between PCV1 and PCV2 In Vitro: Implications for the Role of NLS In Viral Replication
Jiangbing Shuai, Linglin Fu, Xiaofeng Zhang, Binglin Zhu, XiaoLiang Li, Yongqiang He and Weihuan Fang
Abstract (provisional) Background Porcine circovirus type 2 (PCV2) is believed to be the primary causative agent of postweaning multisystemic wasting syndrome (PMWS). It is supposed that capsid protein of PCV may contribute to replication control via...

Published Jun 2011: Animal Reproduction Science Volume 126, Issues 1-2, June 2011, Pages 108-114
Removal of Virus from Boar Semen Spiked with Porcine Circovirus Type 2
Gunilla Blomqvist, Maria Persson, Margareta Wallgren, Per Wallgren, Jane M. Morrell
The virus porcine circovirus type 2 (PCV2) is associated with different disease entities, including reproductive failure. The objective of this study was to investigate the use of a semen processing technique for the elimination of infectious PCV2 in...

Published Jun 2011: Virus Research Volume 158, Issues 1-2, June 2011, Pages 281-288
Natural Recombinants Derived from Different Patterns of Recombination Between two PCV2b Parental Strains
Lin Cai, Xue Han, Jianqiang Ni, Xiuling Yu, Zhi Zhou, Xinyan Zhai, Xizhao Chen, Kegong Tian
Porcine circovirus diseases (PCVD) are globally emerging diseases that have huge economic impacts on swine industry. Porcine circovirus type 2 (PCV2) is considered to be the essential primary causative agent of PCVD. In the present study, recombination...

Published Jun 2011: Veterinary Microbiology
Microarray and Cytokine Analyses of Field Cases of Pigs with Diarrhoea
M. Jacobsona, M. Andersson, R. Lindberg, C. Fossum and M. Jensen-Waern
This field study explored the cytokine expression in intestinal tissue and serum from 19 diarrhoeic and 9 healthy pigs in herds with a long-time history of Lawsonia intracellularis-infection. The disease, proliferative enteropathy (PE), is associated...

Published Jun 2011: Virology Journal 2011, 8:291
First Construction of Infectious Clone for Newly Emerging Mutation Porcine Circovirus Type 2 (PCV2) Followed by Comparison with PCV2a and PCV2b Genotypes in Biological Characteristics in vitro
Long J Guo, Yue H Lu, Li P Huang, Yan W Wei, Hong L Wu and Chang M Liu
Background Porcine circovirus type 2 (PCV2), the causative agent of postweaning multisystemic wasting syndrome (PMWS), is a serious economic problem in the swine industry. Different genotypes (PCV2a, PCV2b and PCV2d) of the virus are present in the clinical...

Published Jun 2011: Proteomics
Quantitative Proteomics by 2-DE, 18O/16O Labeling and Linear ION Trap Mass Spectrometry Analysis of Lymph Nodes from Piglets Inoculated by Porcine Circovirus Type 2 (PCV2)
María Ramírez-Boo1, Estefania Núnez, Inmaculada Jorge, Pedro Navarro, Lana T. Fernandes, Joaquim Segalés, Juan J. Garrido1, Jesús Vázquez, Ángela Moreno1
Porcine circovirus type 2 (PCV-2) has been identified as the essential causal agent of postweaning multisystemic wasting syndrome (PMWS). However, little is known regarding the mechanism(s) underlying the pathogenesis of PCV-2-induced disease and the...

Published May 2011: Virus Research Volume 161, Issue 2, November 2011, Pages 115-123
Construction and Biological Characterisation of Recombinant Porcine Circovirus Type 2 Expressing the V5 Epitope Tag
Liping Huang, Yuehua Lu, Yanwu Wei, Longjun Guo, Hongli Wu, Feiyan Zhang, Yujie Fu, Changming Liu
Porcine circovirus type 2 (PCV2) is a major causal agent of post-weaning multisystemic wasting syndrome in piglets. To investigate the feasibility of PCV2 expressing an exogenous epitope, a 14-amino-acid V5 epitope derived from simian parainfluenza...

Published May 2011: Virology Journal 2011, 8:264
Co-expression of Ubiquitin Gene and Capsid Protein Gene Enhances the Potency of DNA Immunization of PCV2 in Mice
Fang Fu, Xuesong Li, Yuekun Lang, Yuju Yang, Guangzhi Tong, Guoxin Li, Yanjun Zhou and Xi Li
A recombinant plasmid that co-expressed ubiquitin and porcine circovirus type 2 (PCV2) virus capsid protein (Cap), denoted as pc-Ub-Cap, and a plasmid encoding PCV2 virus Cap alone, denoted as pc-Cap, were transfected into 293T cells. Indirect immunofluorescence...

Published May 2011: J Clin Microbiol. 2011 May; v.49(5)
Characterization of a New Disease Syndrome Associated with Porcine Circovirus Type 2 in Previously Vaccinated Herds
Ada G. Cino-Ozuna,1 Steven Henry,2 Richard Hesse, Jerome C. Nietfeld, Jianfa Bai, H. Morgan Scott and Raymond R. R. Rowland
Porcine circovirus-associated disease (PCVAD) encompasses a group of wasting syndromes linked to porcine circovirus type 2 (PCV2). This paper describes a new PCV2 disease syndrome, called acute pulmonary edema (APE), which, unlike other PCVAD syndromes,...

Published May 2011: Veterinary Microbiology Article in Press, Accepted Manuscript
Dynamics of Torque Teno Sus Virus 1 (TTSuV1) and 2 (TTSuV2) DNA Loads in Serum of Healthy and Postweaning Multisystemic Wasting Syndrome (PMWS) Affected Pigs
D. Nietoa, M. Aramounia, L. Grau-Romaa, J. Segalés and T. Kekarainen
Torque teno viruses (TTVs) are vertebrate infecting, small viruses with circular single stranded DNA, classified in the Anelloviridae family. In pigs, two different TTV species have been described so far, Torque teno sus virus 1 (TTSuV1) and 2 (TTSuV2)....

Published May 2011: Vaccine, In Press, Uncorrected Proof
Molecular and Infectivity Studies of Porcine Circovirus in Vaccines
Shasta D. McClenahan, Philip R. Krause, Christine Uhlenhaut
This report describes FDA's laboratory response to the 2010 reports that porcine circovirus type 1 (PCV-1) DNA was present in U.S.-licensed rotavirus vaccines and in cells used to produce inactivated poliovirus vaccines. In the present study, Rotarix®...

Published May 2011: Research in Veterinary Science, In Press, Corrected Proof,
Natural Co-Infection of Torque Teno Virus and Porcine Circovirus 2 in the Reproductive Apparatus of Swine
Giseli A. Ritterbusch, Camila A. Sa Rocha, Nelson Mores, Neide L. Simon, Eraldo L. Zanella, Arlei Coldebella, Janice R. Ciacci-Zanella
This work aimed to detect and study natural co-infection of Circoviridae torque teno virus (TTV) and porcine circovirus 2 (PCV2) in the swine reproductive apparatus. Semen and organs from 17 boars were tested by nested and real-time PCR. PCV2 was amplified...

Published May 2011: Veterinary Immunology and Immunopathology, In Press, Accepted Manuscript
Intestinal Gene Expression in Pigs Experimentally Co-Infected with PCV2 and PPV
M. Andersson, V. Ahlberg, M. Jensen-Waern, C. Fossum
The objective of the present study was to characterize the local immune reaction in the intestine of pigs experimentally infected with PCV2 and PPV. Archived intestinal material from an experimental study in which pigs were co-infected with a Swedish...

Published May 2011: Veterinary Microbiology Volume 149, Issues 3-4, 5 May 2011, Pages 339-351
One Dose of a Porcine Circovirus 2 Subunit Vaccine Induces Humoral and Cell-Mediated Immunity and Protects Against Porcine Circovirus-Associated Disease under Field Conditions
Paolo Martelli, Luca Ferrari, Marina Morganti, Elena De Angelis, Paolo Bonilauri, Stefano Guazzetti, Antonio Caleffi, Paolo Borghetti
This study investigated the efficacy of a one-dose porcine circovirus 2 (PCV2) subunit vaccine based on the PCV2 Cap protein expressed in a baculovirus system on two different farms at which a history of porcine circovirus-associated disease (PCVD) was...

Published May 2011: Veterinary Microbiology - Volume 149, Issues 3-4, 5 May 2011, Pages 352-357
Post-Weaning Multisystemic Wasting Syndrome (PMWS) Clinical Expression Under Field Conditions is Modulated by the Pig Genetic Background
Sergio López-Soria, Miquel Nofrarías, Maria Calsamiglia, Anna Espinal, Oliver Valero, Humberto Ramírez-Mendoza, Almudena Mínguez, José M. Serrano, Óscar Marín, Antonio Callén, Joaquim Segalés
Post-weaning multisystemic wasting syndrome (PMWS) is a worldwide distributed disease of multifactorial origin and porcine circovirus type 2 (PCV2) has been identified as its essential infectious aetiology. Pig genetic background has been pointed to influence...

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