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PMWS Research Archives
Published Sep 2010: Vet J. 2010 Sep 2. [Epub ahead of print]Apoptosis in Postweaning Multisystemic Wasting Syndrome (PMWS) Hepatitis in Pigs Naturally Infected with Porcine Circovirus Type 2 (PCV2).
Resendes AR, Majó N, van den Ingh TS, Mateu E, Domingo M, Calsamiglia M, Segalés J.
The degree of apoptosis in the livers of pigs with hepatitis due to naturally-occurring postweaning multisystemic wasting syndrome (PMWS) was evaluated semi-quantitatively by immunohistochemical detection of the apoptotic marker cleaved caspase-3 (CCasp3)....
Published Sep 2010: Virus Res. 2010 Sep;152(1-2):59-64. Epub 2010 Jun 11.
Studies of Porcine Circovirus Type 2, Porcine Boca-Like Virus and Torque Teno Virus Indicate the Presence of Multiple Viral Infections in Postweaning Multisystemic Wasting Syndrome Pigs.
Blomström AL, Belák S, Fossum C, Fuxler L, Wallgren P, Berg M.
In a previous study, using random amplification and large-scale sequencing technology, we identified a novel porcine parvovirus belonging to the genus Bocavirus in the background of porcine circovirus type 2 (PCV-2) in Swedish pigs with postweaning multisystemic...
Published Sep 2010: J. Virol., Sep 2010; 84: 8986 - 8989.
Replacement of the Replication Factors of Porcine Circovirus (PCV) Type 2 with Those of PCV Type 1 Greatly Enhances Viral Replication In Vitro
N. M. Beach, N. M. Juhan, L. Cordoba, and X. J. Meng
Porcine circovirus type 1 (PCV1), originally isolated as a contaminant of PK-15 cells, is nonpathogenic, whereas porcine circovirus type 2 (PCV2) causes an economically important disease in pigs. To determine the factors affecting virus replication, we...
Published Aug 2010: Prev Vet Med. 2010 Aug 27. [Epub ahead of print]
A Cohort Study of Post-Weaning Multisystemic Wasting Syndrome and PCV2 in 178 Pigs from Birth to 14 Weeks on a Single Farm in England.
Woodbine KA, Turner MJ, Medley GF, Scott PD, Easton AJ, Slevin J, Brown JC, Francis L, Green LE.
Our hypothesis was that pigs that develop post-weaning multisystemic wasting syndrome (PMWS) are detectable from an early age with signs of weight loss and other clinical and serological abnormalities. Therefore, the objective of this study was to investigate...
Published Aug 2010: Pig Journal Volume: 63 - August 2010
PMWS in Sweden - From an Exotic to an Endemic Disease
P.WALLGREN
Post-weaning multisystemic wasting syndrome (PMWS) was diagnosed for the first time in Sweden at a progeny test station in December 2003. By December 2006, 126 herds had been diagnosed with PMWS and the disease was regarded as endemic and was removed...
Published Aug 2010: Pig Journal Volume: 63 August 2010
Prevalence of Endemic Pig Disease in England: An Overview Six Months into a Large Scale Cross Sectional Study on Post-Weaning Multisytemic Wasting Syndrome (PMWS)
B. WEILAND, P. ALARCON, M. VELASOVA, A. NEVEL, H. TOWRIE, D. PFEIFFER, C. WATHES, D. WERLING
In April 2008 the Royal Veterinary College implemented a large scale cross-sectional study investigating risk factors affecting severity of Post- Weaning Multisystemic Wasting Syndrome (PMWS) on farms. Six months into the study 114 farms have been recruited...
Published Aug 2010: Vet Immunol Immunopathol. 2010 Aug 15;136(3-4):185-93. Epub 2010 Apr 7.
Immune Responses and Vaccine-Induced Immunity against Porcine Circovirus Type 2.
Kekarainen T, McCullough K, Fort M, Fossum C, Segalés J, Allan GM.
Porcine circovirus type 2 (PCV2) is essential but not sufficient for postweaning multisystemic wasting syndrome (PMWS) occurrence in pigs. The outcome of PCV2 infection depends on the specific immune responses that are developing during the infection....
Published Aug 2010: Vet Immunol Immunopathol. 2010 Aug 15;136(3-4):305-10. Epub 2010 Mar 17.
Increased Numbers of Myeloid and Lymphoid IL-10 Producing Cells in Spleen of Pigs with Naturally Occurring Postweaning Multisystemic Wasting Syndrome.
Crisci E, Ballester M, DomÃnguez J, Segalés J, Montoya M.
Porcine circovirus type 2 (PCV2) is the essential etiological agent of postweaning multisystemic wasting syndrome (PMWS), a worldwide distributed pig disease. The involvement of the immune system in the pathogenesis of PMWS is considered crucial. Previous...
Published Jul 2010: Virol J. 2010 Jul 21;7:166.
Self-Assembly of Virus-Like Particles of Porcine Circovirus Type 2 Capsid Protein Expressed from Escherichia Coli.
Yin S, Sun S, Yang S, Shang Y, Cai X, Liu X.
BACKGROUND: Porcine circovirus 2 (PCV2) is a serious problem to the swine industry and can lead to significant negative impacts on profitability of pork production. Syndrome associated with PCV2 is known as porcine circovirus closely associated...
Published Jul 2010: Analyst. 2010 Jul;135(7):1680-5. Epub 2010 May 27.
Ultrasensitive Detection of Porcine Circovirus Type 2 Using Gold(III) Enhanced Chemiluminescence Immunoassay.
Zhang H, Li W, Sheng Z, Han H, He Q.
Porcine circovirus type 2 (PCV2) is associated with many diseases especially postweaning multisystemic wasting syndrome (PMWS), which has brought huge economic loss to the swine industry worldwide. Viral detection will pave the way for this disease prevention....
Published Jul 2010: Prev Vet Med. 2010 Jul 1;95(3-4):239-47. Epub 2010 May 14.
Antimicrobial use in Danish Pig Herds with and without Postweaning Multisystemic Wasting Syndrome.
Jensen VF, Enøe C, Wachmann H, Nielsen EO.
A retrospective cohort study was performed on 130 pig herds in Denmark, to assess the effect of PMWS on the use of antimicrobial drug. The study comprised 65 herds diagnosed with PMWS during 2003-2004, and matched by the veterinary practitioner with 65...
Published May 2010: Res Vet Sci. 2010 May 23. [Epub ahead of print]
Genetic Typing of Porcine Circovirus Type 2 (PCV-2) Isolates from Slovakia.
Vlasakova M, Jackova A, Vilcek S.
Of 120 clinical specimens obtained from pigs bred on 28 PMWS-affected farms in Slovakia, porcine circovirus type 2 (PCV-2) was detected by single PCR in 77 samples. A short 224bp fragment of ORF2 was used for preliminary grouping of isolates by phylogenetic...
Published May 2010: Journal of Virological Methods, Volume 165, Issue 2, May 2010, Pages 222-229
Characterization and Epitope Mapping of Monoclonal Antibodies Recognizing N-Terminus of Rep of Porcine Circovirus Type 2
Tao Meng, Qiang Jia, Sen Liu, Anbu K. Karuppannan, Chih-Cheng Chang, Jimmy Kwang
Two genotypes of porcine circovirus (PCV) have been described, the non-pathogenic PCV1 and the pathogenic PCV2 in pigs. PCV-ORF1 encodes Rep and Rep’ proteins which have identical N-terminal sequence (RepN) within each PCV strain, but RepN has only...
Published May 2010: Journal of Virological Methods, Volume 165, Issue 2, May 2010, Pages 216-221
LUX Real-Time PCR Assay for the Detection of Porcine Circovirus Type 2
Stefan Vilcek, Michaela Vlasakova, Anna Jackova
Light Upon eXtension real-time PCR (LUX real-time PCR) assay was developed for the detection of porcine circovirus type 2 (PCV2). The primers flanking a 114 bp fragment were selected from ORF1. The optimized assay could detect 20 viral copies of pBluescript...
Published Apr 2010: Virus Genes. 2010 Apr;40(2):244-51. Epub 2009 Dec 31.
Genetic Analysis of Porcine Circovirus Type 2 (PCV2) Strains Isolated Between 2001 and 2009: Genotype PCV2b Predominate in Postweaning Multisystemic Wasting Syndrome Occurrences in Eastern China.
Li W, Wang X, Ma T, Feng Z, Li Y, Jiang P.
Porcine circovirus type 2 (PCV2) is the essential infectious agent of postweaning multisystemic wasting syndrome (PMWS). In the present study, we obtained sequences of 31 PCV2 isolates from different farms of 11 provinces of eastern China and analyzed...
