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PMWS Research Archives

Published May 2011: Veterinary Microbiology - Volume 149, Issues 3-4, 5 May 2011, Pages 452-455
House Fly Vector for Porcine Circovirus 2b on Commercial Pig Farms
R. Blunt, S. McOrist, J. McKillen, I. McNair, T. Jiang, K. Mellits
We investigated the on-farm potential of common farm invertebrates to transmit porcine circovirus genotype 2 (PCV2) and other non-enveloped viruses. In 2007 (pre-PCV2 vaccination) and 2008 (post-PCV2 vaccination), invertebrate communities were trap-collected...

Published May 2011: Veterinary Microbiology Volume 149, Issues 3-4, 5 May 2011, Pages 352-357
Post-Weaning Multisystemic Wasting Syndrome (PMWS) Clinical Expression Under Field Conditions is Modulated by the Pig Genetic Background
Sergio López-Soria, Miquel Nofrarías, Maria Calsamiglia, Anna Espinal, Oliver Valero, Humberto Ramírez-Mendoza, Almudena Mínguez, José M. Serrano, Óscar Marín, Antonio Callén and Joaquim Segalés
Post-weaning multisystemic wasting syndrome (PMWS) is a worldwide distributed disease of multifactorial origin and porcine circovirus type 2 (PCV2) has been identified as its essential infectious aetiology. Pig genetic background has been pointed to influence...

Published May 2011: Journal of Comparative Pathology Volume 144, Issue 4, May 2011, Pages 296-302
Porcine Circovirus-2 Viral Load Versus Lesions in Pigs: Perspectives for Post-weaning Multisystemic Wasting Syndrome
F.M.F. Silva, A. Silva Júnior, P.M.P. Vidigal, C.R. Oliveira, V.W. Viana, C.H.O. Silva, M.I. Vargas, J.L.R. Fietto, M.R. Almeida
Porcine circovirus-2 (PCV-2) is the main agent related to post-weaning multisystemic wasting syndrome (PMWS) and it is also associated with other syndromes affecting pigs. Not all pigs infected with PCV-2 will develop PMWS and the incidence of PMWS is...

Published Apr 2011: Can Vet J - v.52(4); Apr 2011
Unusual Central Nervous System Lesions in Slaughter-Weight Pigs with Porcine Circovirus Type 2 Systemic Infection
Richard Drolet, François Cardinal, Alain Houde, and Carl A. Gagnon
Porcine circovirus type 2 systemic infection was diagnosed in 2 slaughter-weight pigs based on postmortem examination. The infection was associated with unusual central nervous system lesions characterized by a multifocal lymphohistiocytic to granulomatous...

Published Apr 2011: Australian Veterinary Journal Volume 89, Issue 4, pages 122-130
Porcine Circovirus-Associated Disease in Weaner Pigs in Western Australia
M A O'Dea, M J Kabay, J Carr, G E Wilcox, R B Richards
Objective To report the occurrence and pathology of porcine circovirus type 2 (PCV2)-associated disease (PCVAD) of postweaning pigs in two Australian pig herds. Methods Mortality data from two commercial piggeries that experienced higher than normal...

Published Apr 2011: Veterinary Record 2011;168:512 doi:10.1136/vr.c7303
PMWS Associated with Diarrhoea and Illthrift in a Captive Red River Hog (Potamochoerus porcus)
N. G. A. Woodger, O. M. Hosegood
POSTWEANING multisystemic wasting syndrome (PMWS) emerged as a disease with a major economic impact on the pig industry in several pig-producing countries across the northern hemisphere in the 1990s. The disease has characteristic pathological features...

Published Apr 2011: Research in Veterinary Science, Volume 90, Issue 2, April 2011, Pages 321-323
Proinflammatory Cytokine Expression in the Lung of Pigs with Porcine Circovirus Type 2-Associated Respiratory Disease
Joon-Seok Chae, Kyoung-Seong Choi
Porcine circovirus type 2 (PCV2) causes a significant health problem for the swine industry worldwide. In this study, we investigated the cytokine expression profiles (IFN-γ, IL-1α, IL-8, and IL-10) in the lungs of pigs with PCV2-associated...

Published Mar 2011: Veterinary Microbiology Volume 148, Issues 2-4, 24 March 2011, Pages 372-376
Distribution of ORF2 and ORF3 Genotypes of Porcine Circovirus Type 2 (PCV-2) in Wild Boars and Domestic Pigs in Germany
Gerald Reiner, Bastian Bronnert, Corinna Hohloch, Manfred Reinacher, Hermann Willems
Porcine circovirus 2 (PCV-2), the essential infectious agent in PCVD (porcine circovirus diseases) circulates at high rates among domestic pig and wild boar populations. Wild boars may be viremic and shed the virus with excretions and secretions, and...

Published Mar 2011: Veterinary Research 2011, 42:54
Modification of PCV-2 Virulence by Substitution of the Genogroup Motif of the Capsid Protein
Aude Allemandou, Beatrice Grasland, Anne-Cecile Hernandez-Nignol, Andre Keranflec'h, Roland Cariolet and Andre Jestin
Porcine circovirus type 2 (PCV-2) is the causal agent of the post-weaning multisystemic wasting syndrome (PMWS). PCV-2 are small single-stranded circular DNA viruses clustered into two main genogroups: PCV-2a and PCV-2b. Each genogroup presents a specific...

Published Mar 2011: Clin Vaccine Immunol. 2011 Mar 23. [Epub ahead of print]
Antibody Recognition of Porcine Circovirus Type 2 Capsid Protein Epitopes after Vaccination, Infection and Disease.
Trible BR, Kerrigan M, Crossland N, Potter M, Faaberg K, Hesse R, Rowland RR.
Open reading frame 2 (ORF2) of porcine circovirus type 2 (PCV2) codes for the 233 amino acid capsid protein (CP). Baculovirus-based vaccines that express only ORF2 are protective against clinical disease following experimental challenge or natural infection....

Published Mar 2011: J Vet Diagn Invest. 2011 Mar;23(2):233-40.
Theoretical and Experimental Approaches to Estimate the Usefulness of Pooled Serum Samples for the Diagnosis of Postweaning Multisystemic Wasting Syndrome.
Cortey M, Napp S, Alba A, Pileri E, Grau-Roma L, Sibila M, Segalés J.
Classical postweaning multisystemic wasting syndrome (PMWS) diagnosis is based on postmortem findings (histopathology plus viral detection in lymphoid tissues). Because one of the major differences between PMWS-affected and nonaffected pigs is Porcine...

Published Mar 2011: Virology Journal 2011, 8:126
Specific, Simple and Rapid Detection of Porcine Circovirus Type 2 using the Loop-Mediated Isothermal Amplification Method
Zhao K, Shi W, Han F, Xu Y, Zhu L, Zou Y, Wu X, Zhu H, Tan F, Tao S, Tang X
Abstract Background Porcine circovirus type 2 (PCV2) is the causative agent of postweaning multisystemic wasting syndrome (PMWS), and porcine dermatitis and nephropathy syndrome (PDNS). It has caused heavy losses in global agriculture in recent decades....

Published Mar 2011: Preventive Veterinary Medicine Volume 98, Issue 4, 1 March 2011, Pages 250-258
A Meta-Analysis Comparing the Effect of PCV2 Vaccines on Average Daily Weight Gain and Mortality Rate in Pigs From Weaning to Slaughter
Charlotte Sonne Kristensen, Niels Peter Baadsgaard, Nils Toft
The aim of this investigation was, through a meta-analysis, to review the published literature concerning the effect of PCV2 vaccination on the average daily weight gain (ADG) and on the mortality rate in pigs from weaning to slaughter. The review...

Published Feb 2011: Virology Journal 2011, 8:88
Genetic Characterization of Porcine Circovirus Type 2 in Piglets from PMWS-Affected and -Negative Farms in Thailand
Tippawan Jantafong, Alongkot Boonsoongnern, Pariwat Poolperm, Kitcha Urairong, Chalermpol Lekcharoensuk and Porntippa Lekcharoensuk
Porcine circovirus type 2 (PCV2) is the major swine pathogen associated with Porcine circovirus associated disease (PCVAD) including post-weaning multisystemic wasting syndrome (PMWS). Currently, there are 4 subtypes of PCV2 (PCV2a, b, c and d) and some...

Published Feb 2011: Veterinary Immunology and Immunopathology Volume 139, Issues 2-4, 15 February 2011, Pages 156-166
Cytokine Induction by Immunostimulatory DNA in Porcine PBMC is Impaired by a Hairpin Forming Sequence Motif from the Genome of Porcine Circovirus Type 2 (PCV2)
F. Hasslung Wikströma, C. Fossuma,L. Fuxler, R. Kruse and T. Lövgren
Porcine Circovirus type 2 (PCV2) can cause postweaning multisystemic wasting syndrome (PMWS) in young pigs with severe immunosuppression as a major characteristic of the disease complex. Despite the dramatic involvement of the immune system, the interaction...

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