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PMWS Research Archives
Published Apr 2008: J Virol Methods. 2008 Apr 2 (Epub ahead of print)Construction and immunogenicity of recombinant pseudotype baculovirus expressing the capsid protein of porcine circovirus type 2 in mice.
Fan H, Pan Y, Fang L, Wang D, Wang S, Jiang Y, Chen H, Xiao S.
Baculovirus has emerged recently as a novel and attractive gene delivery vehicle for mammalian cells. Porcine circovirus type 2 (PCV2) is known to be associated with post-weaning multisystemic wasting syndrome (PMWS), an emerging swine disease which results...
Published Apr 2008: New Zealand Veterinary Journal, Volume 56, Number 2, April 2008 , pp. 94-99(6)
Porcine dermatitis and nephropathy syndrome in New Zealand
Johnstone, A.C.; Lawton
Abstract CASE HISTORY: An outbreak of fatal or debilitating disease characterised by wasting and cutaneous lesions that usually necessitated euthanasia, occurred over a period of 4 months in pigs 14-16 weeks of age from a commercial 'farrow-to-finish'...
Published Mar 2008: Virus Genes. 2008 Mar 15 (Epub ahead of print)
Phylogenetic analysis of porcine circovirus type 2 (PCV2) pre- and post-epizootic postweaning multisystemic wasting syndrome (PMWS).
Timmusk S, Wallgren P, Brunborg IM, Wikström FH, Allan G, Meehan B, McMenamy M, McNeilly F, Fuxler L, Belák K, Põdersoo D, Saar T, Berg M, Fossum C.
The porcine circovirus type 2 (PCV2) genome encodes three major open reading frames (ORFs) encoding the replicase proteins (ORF1), the viral capsid protein (ORF2), and a protein with suggested apoptotic activity (ORF3). Previous phylogenetic analyses...
Published Mar 2008: Research in Veterinary Science, Volume 84, Issue 2, April 2008, Pages 194-198
Transient correlation between viremia levels and IL-10 expression in pigs subclinically infected with porcine circovirus type 2 (PCV2)
L. Darwich, J. Segalés, A. Resendes, M. Balasch, J. Plana-Durán and E. Mateu
Immunological impairment by porcine circovirus type 2 (PCV2) infection is well documented in pigs suffering from postweaning multisystemic wasting syndrome. Nonetheless, little is known about immune status of pigs that remain PCV2 subclinically infected....
Published Mar 2008: J Gen Virol 89 (2008), 760-765;
Porcine circovirus type 2-induced interleukin-10 modulates recall antigen responses
Tuija Kekarainen, Maria Montoya, Enric Mateu1 and Joaquim Segalés
Porcine circovirus type 2 (PCV2) is the necessary agent for the occurrence of post-weaning multisystemic wasting syndrome (PMWS) in pigs. It has been suggested that PMWS-affected pigs are immunosuppressed and, therefore, more prone to develop co-infections....
Published Mar 2008: Vaccine, Volume 26, Issue 11, 10 March 2008, Pages 1488-1499
The effect of vaccination against porcine circovirus type 2 in pigs suffering from porcine respiratory disease complex
Vicky Fachinger, Ralf Bischoff, Samir Ben Jedidia, Armin Saalmüller and Knut Elbers
A field study was conducted to investigate the effect of vaccination against porcine circovirus type 2 (PCV2) in pigs suffering from porcine respiratory disease complex (PRDC). A total of 1542 pigs were allocated randomly into two treatment groups at...
Published Mar 2008: Antiviral Research, Volume 77, Issue 3, March 2008, Pages 186-194
Adenovirus-mediated shRNA interference against porcine circovirus type 2 replication both in vitro and in vivo
Zhixin Feng, Ping Jiang, Xianwei Wang, Yufeng Li and Wenming Jiang
Porcine circovirus type 2 (PCV2) is the primary causative agent of an emerging swine disease, postweaning multisystemic wasting syndrome (PMWS), which is responsible for the heavy economic losses in stockbreeding. There are no specific antiviral drugs...
Published Mar 2008: Virus Research, Volume 132, Issues 1-2, March 2008, Pages 201-207
Evidence for recombination between PCV2a and PCV2b in the field
Richard Hesse, Maureen Kerrigan and Raymond R.R. Rowland
Genomic sequence analysis demonstrates that porcine circovirus type 2 (PCV2) isolates are divided into distinct genotypes. Historically, swine herds in the U.S. have been infected with the PCV2a genotype. In 2005, PCV2b was identified in North America...
Published Feb 2008: Vaccine, Volume 26, Issue 8, 20 February 2008, Pages 1063-1071
Porcine circovirus type 2 (PCV2) vaccination of conventional pigs prevents viremia against PCV2 isolates of different genotypes and geographic origins
M. Fort, M. Sibila, A. Allepuz, E. Mateu, F. Roerink and J. Segalés
The efficacy of recently developed porcine circovirus type 2 (PCV2) vaccines has not been tested yet against PCV2 isolates of the two proposed genotypes. In the present work, the efficacy of a subunit vaccine containing PCV2 capsid protein was evaluated...
Published Feb 2008: Res Vet Sci. 2008 Feb;84(1):150-7. Epub 2007 Apr 30
Development and validation of a recombinant capsid protein-based ELISA for detection of antibody to porcine circovirus type 2.
Shang SB, Li YF, Guo JQ, Wang ZT, Chen QX, Shen HG, Zhou JY.
Porcine circovirus type 2 (PCV2) has been recently associated with a number of disease syndromes, especially postweaning multisystemic wasting disease (PMWS). Herein, an alternative indirect enzyme-linked immunosorbent assay (ELISA) for detection of PCV2...
Published Jan 2008: Wei Sheng Wu Xue Bao. 2008 Jan 4;48(1):85-90
Characterization and potential use of truncated PCV2 capsid protein and its polyclonal antibody for diagnosis of PCV2 infections.
Shuai J, Li X, Chen N, Chen X, Fang W.
As porcine circovirus 2 (PCV2) ORF2 encodes the major structural protein (capsid) that is closely related to the pathogenesis, the capsid (Cap) protein could be used as a target antigen for serological analysis. The immunoactivities of the truncated capsid...
Published Jan 2008: J Gen Virol 89 (2008), 177-187; DOI 10.1099/vir.0.83280-0
Antigenic differences among porcine circovirus type 2 strains, as demonstrated by the use of monoclonal antibodies
D. J. Lefebvre, S. Costers, J. Van Doorsselaere, G. Misinzo, P. L. Delputte and H. J. Nauwynck
This study examined whether antigenic differences among porcine circovirus type 2 (PCV-2) strains could be detected using monoclonal antibodies (mAbs). A subtractive immunization protocol was used for the genotype 2 post-weaning multisystemic wasting...
Published Jan 2008: Journal of Virological Methods - Volume 147, Issue 1, January 2008, Pages 61-66
Thermal stability of porcine circovirus type 2 in cell culture
Mark A. O’Dea, Andrew P. Hughes, Linda J. Davies, Jillian Muhling, Ross Buddle and G.E. Wilcox
Received 2 May 2007; revised 25 July 2007; accepted 30 July 2007. Available online 21 September 2007. International trade in pig meat has resulted in some countries placing restrictions on the importation of pig meat, with requirements for cooking...
Published Jan 2008: Journal of Biotechnology - Volume 133, Issue 1, 1 January 2008, Pages 58-64
Expression of the porcine circovirus type 2 capsid protein subunits and application to an indirect ELISA
Pei-Ching Wu, Maw-Sheng Chien, Yu-Yao Tseng, Jiarong Lina Wei-Li Lin, Cheng-Yao Yang and Chienjin Huang
Received 18 April 2007; revised 24 August 2007; accepted 19 September 2007. Available online 2 October 2007. Porcine circovirus type 2 (PCV2) is considered to be associated with post-weaning multisystemic wasting syndrome (PMWS), which is a newly...
Published Dec 2007: New Zealand Veterinary Journal, Volume 55, Number 6, December 2007 , pp. 346-352(7)
Descriptive summary of an outbreak of porcine post-weaning multisystemic wasting syndrome (PMWS) in New Zealand
Neumann, E.J.; Dobbinson, S.S.A.; Welch, E.B.M.; Morris, R.S.
CASE HISTORY: Investigations were conducted to determine the cause of an acute, multi-farm outbreak of porcine respiratory disease that included diarrhoea and subsequent loss of body condition in affected pigs. A definition for post-weaning multisystemic...
