PMWS Research Archives

Published Jan 2010: Veterinary Microbiology, In Press, Corrected Proof, Available online 11 January 2010
Selection of Method is Crucial for the Diagnosis of Porcine Circovirus Type 2 Associated Reproductive Failures
Mette S. Hansen, Charlotte K. Hjulsager, Vivi Bille-Hansen, Svend Haugegaard, Kitt Dupont, Peter Høgedal, Lars Kunstmann, Lars E. Larsen
During a 2-month period a newly repopulated Danish pig herd experienced an increase in numbers of stillborn and mummies, caused by porcine circovirus type 2 (PCV2) associated reproductive failure. Based on recordings of data over time, the progression...

Published Jan 2010: Veterinary Microbiology, Volume 140, Issues 1-2, 6 January 2010, Pages 155-160
Cytokine mRNA Expression Profiles in Peripheral Blood Mononuclear Cells from Piglets Experimentally Co-infected with Porcine Reproductive and Respiratory Syndrome Virus and Porcine Circovirus Type 2
Kai-Chuang Shi, Xin Guo, Xin-Na Ge, Qi Liu, Han-Chun Yang
Porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) significantly impact the swine industry worldwide. Co-infections with these viruses are common and several lines of evidence suggest that both PRRSV and PCV2...

Published Jan 2010: Vaccine. 2010 Jan 5. [Epub ahead of print]
Immunity Conferred by an Experimental Vaccine Based on the Recombinant PCV2 Cap Protein Expressed in Trichoplusia Ni-Larvae.
Pérez-Martín E, Gómez-Sebastián S, Argilaguet JM, Sibila M, Fort M, Nofrarías M, Kurtz S, Escribano JM, Segalés J, Rodríguez F.
Porcine circovirus type 2 (PCV2) vaccination has been recently included as a measure to control postweaning multisystemic wasting syndrome (PMWS) in the field. Aiming to obtain a more affordable vaccine to be extensively implemented in the field, a highly...

Published Dec 2009: BMC Vet Res. 2009 Dec 22;5:45.
Cellular Adaptive Immune Response against Porcine Circovirus Type 2 in Subclinically Infected Pigs.
Steiner E, Balmelli C, Gerber H, Summerfield A, McCullough K.
BACKGROUND: Porcine circovirus type 2 (PCV2) is a dominant causative agent of postweaning multisystemic wasting syndrome (PMWS), a multifactorial disease complex with putative immunosuppressive characteristics. Little is known about adaptive PCV2-specific...

Published Dec 2009: J. Virol., Dec 2009; 83: 12813 - 12821.
Insights into the Evolutionary History of an Emerging Livestock Pathogen: Porcine Circovirus 2
Cadhla Firth, Michael A. Charleston, Siobain Duffy, Beth Shapiro, and Edward C. Holmes
Porcine circovirus 2 (PCV2) is the primary etiological agent of postweaning multisystemic wasting syndrome (PMWS), one of the most economically important emerging swine diseases worldwide. Virulent PCV2 was first identified following nearly simultaneous...

Published Nov 2009: Sheng Wu Gong Cheng Xue Bao. 2009 Nov;25(11):1639-45.
[Construction and Immunogenicity of Recombinant Adenoviruses Expressing Cap Protein of PCV2 and GP5 Protein of PRRSV in Mice]
Wang X, Li Y, Jiang P.
Porcine circovirus 2 (PCV2) has been implicated as the etiological agent of postweaning multisystemic wasting syndrome (PMWS). Co-infection of PCV2 and porcine reproductive and respiratory syndrome virus (PRRSV) can result in severe economic losses to...

Published Nov 2009: Veterinary Microbiology, In Press, Corrected Proof, Available online 19 November 2009
Dietary Aluminosilicate Supplement Enhances Immune Activity in Mice and Reinforces Clearance of Porcine Circovirus Type 2 in Experimentally Infected Pigs
Bock-Gie Jung, Nguyen Tat Toan, Sun-Ju Cho, Jae-hyung Ko, Yeon-Kwon Jung, Bong-Joo Lee
Aluminosilicate is the major component of clay minerals such as zeolite, bentonite and clinoptilolite. The minerals possess a number of beneficial activities, especially in regulating the immune system. The aims of the present study were to evaluate immune...

Published Nov 2009: Journal of Comparative Pathology, Volume 141, Issue 4, November 2009, Page 312
PCV2-Associated Myocarditis with Necrosis in a Feeder Pig
D. Wiederkehr, H. Weibel, X. Sidler

Published Nov 2009: Journal of Comparative Pathology, Volume 141, Issue 4, November 2009, Page 290
Infection by Porcine Circovirus Type 2 in Wild Boars in Germany
C. Hohloch, M. Reinacher

Published Oct 2009: Veterinary Microbiology, In Press, Corrected Proof, Available online 20 October 2009
A Study on the Severity and Relevance of Porcine Circovirus Type 2 Infections in Dutch Fattening Pigs with Respiratory Diseases
G.J. Wellenberg, F.T. Bouwkamp, P.J.v.d. Wolf, W.A.J.M. Swart, M.J. Mombarg, A.L.W. de Gee
This study was set up to get more insights in the severity and relevance of porcine circovirus type 2 (PCV2) infections in Dutch fattening farms in an endemic PCV2-situation with no clinical signs of post-weaning multisystemic wasting syndrome (PMWS)....

Published Oct 2009: Veterinary Microbiology, In Press, Corrected Proof, Available online 16 October 2009
Comparison of the Effectiveness of Passive (Dam) Versus Active (Piglet) Immunization Against Porcine Circovirus Type 2 (PCV2) and Impact of Passively Derived PCV2 Vaccine-Induced Immunity on Vaccination
Tanja Opriessnig, Abby R. Patterson, Darin M. Madson, Narinder Pal, Sheela Ramamoorthy, Xiang-Jin Meng, Patrick G. Halbur
The objectives of this study were (1) to compare the efficacy of two different PCV2 vaccination protocols (colostrum-derived immunity versus piglet vaccination) in a conventional PCV2 growing pig challenge model and (2) to evaluate the efficacy of vaccinating...

Published Oct 2009: J. Gen. Virol., Oct 2009; 90: 2425 - 2436.
Regulator of G Protein Signalling 16 is a Target for a Porcine Circovirus Type 2 Protein
Sirje Timmusk, Elodie Merlot, Tanja Lövgren, Lilian Järvekülg, Mikael Berg and Caroline Fossum
Interaction studies have suggested that the non-structural protein encoded by open reading frame 3 (ORF3) of porcine circovirus type 2 (PCV2) binds specifically to a regulator of G protein signalling (RGS) related to human RGS16 (huRGS16). The full-length...

Published Oct 2009: The Veterinary Record, Oct 2009; 165: 417 - 418.
Emerging Disease Threat for Pigs?
Peter Bown and Derek Armstrong
......respiratory syndrome (PRRS) and porcine multisystemic wasting syndrome (PMWS). The cause of the syndrome is unknown and farmers and vets have...the greatest threat of introduction. The total cost of PRRS and PMWS over the past two decades runs into...

Published Oct 2009: Canadian Journal Vet Res. 2009 Oct;73(4):308-12.
Prevalence of Infection with Porcine Circovirus-2 (PCV-2) and Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) in an Integrated Swine Production System Experiencing Postweaning Multisystemic Wasting Syndrome.
Fraile L, Calsamiglia M, Mateu E, Espinal A, Cuxart A, Seminati C, Martín M, Domingo M, Segalés J.
The objective of this study was to evaluate the prevalence of infection with porcine circovirus-2 (PCV-2) and porcine reproductive and respiratory syndrome virus (PRRSV) through a longitudinal study in an integrated swine production system (7 farms) experiencing...

Published Sep 2009: Veterinary Microbiology, In Press, Corrected Proof, Available online 11 September 2009
Airborne Porcine Circovirus in Canadian Swine Confinement Buildings
Daniel Verreault, Valérie Létourneau, Louis Gendron, Daniel Massé, Carl A. Gagnon, Caroline Duchaine
Porcine circovirus type 2 has been linked to many diseases, such as postweaning multisystemic wasting syndrome and can be found in most commercial swine confinement buildings around the world. Although the exact role of the virus in the appearance of...

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