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PMWS Research Archives
Published Sep 2004: Vet Pathol. 41(5):471-81.Features of Cell Degeneration and Death in Hepatic Failure and Systemic Lymphoid Depletion Characteristic of Porcine Circovirus-2-associated Postweaning Multisystemic Wasting Disease.
Krakowka S, Ellis J, McNeilly F, Meehan B, Oglesbee M, Alldinger S, Allan G. - Goss Laboratory, Ohio State University, 1925 Coffey Road, Columbus, OH 43210 (USA).
Tissue section replicates from lymphoid tissues and livers of gnotobiotic swine were examined by immunohistochemistry for the colocalization of porcine circovirus-2 (PCV-2) nucleocapsid and terminal deoxynucleotidyl transferase (TdT)-mediated incorporation...
Published Sep 2004: Rev Argent Microbiol. 2004 Jul-Sep;36(3):118-24.
Pathological findings in pigs affected by the postweaning multisystemic wasting syndrome in Argentina
Sarradell J, Perez AM, Comba E, Pereira N, Anthony L, Andrada M, Segales J.
(Article in Spanish) Postweaning multisystemic wasting syndrome was first described in Canada in 1991 and at present an increasing number of cases has been diagnosed worldwide. In Argentina the first cases of PMWS were reported recently. Forty eight...
Published Sep 2004: Journal of Comparative Pathology - August-October 2004 Volume 131, Issues 2-3, Pages 121-126
Expression of Monocyte Chemoattractant Protein-1 and Macrophage Inflammatory Protein-1 in Porcine Circovirus 2-induced Granulomatous Inflammation
J. Kim and C. Chae - Department of Veterinary Pathology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, San 56-1, Shillim-Dong, Kwanak-Gu 141-742, Seoul, South Korea
The expression of monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1 (MIP-1) in granulomatous inflammation of lymph nodes was determined in 1-day-old piglets inoculated intranasally with porcine circovirus 2 (PCV2). The methods...
Published Aug 2004: Journal of Virology, August 2004, p. 8135-8145, Vol. 78, No. 15
Epitope Mapping of the Major Capsid Protein of Type 2 Porcine Circovirus (PCV2) by Using Chimeric PCV1 and PCV2
Porntippa Lekcharoensuk, Igor Morozov, Prem S. Paul, Nattarat Thangthumniyom, Worawidh Wajjawalku, and X. J. Meng
Type 2 porcine circovirus (PCV2) is associated with postweaning multisystemic wasting syndrome in pigs, whereas the genetically related type 1 PCV (PCV1) is nonpathogenic. In this study, seven monoclonal antibodies (MAbs) against PCV2-ORF2 capsid protein...
Published Jul 2004: Research in Veterinary Science 2004 Oct;77(2):171-5.
Detection and genetic characterization of porcine circovirus type 2 (PCV2) in pigs from Croatia.
Jemersic L, Cvetnic Z, Toplak I, Spicic S, Grom J, Barlic-Maganja D, Terzic S, Hostnik P, Lojkic M, Humski A, Habrun B, Krt B. - Virology Department, Croatian Veterinary Institute, Savska cesta 143, 10000 Zagreb, Croatia.
Porcine circovirus type 2 (PCV2) from the Circoviridae family has recently been associated with two serious diseases of swine, post-weaning multisystemic wasting syndrome (PMWS) and porcine dermatitis and nephropathy syndrome (PDNS). During 2002, several...
Published Jul 2004: Research in Veterinary Science 2004 Oct;77(2):177-84.
The presence of co-infections in pigs with clinical signs of PMWS in The Netherlands: a case-control study.
Wellenberg GJ, Stockhofe-Zurwieden N, Boersma WJ, De Jong MF, Elbers AR. - Division of Infectious Diseases, Animal Sciences Group (ID-Lelystad), Edelhertweg 15, P.O. Box 65, 8200 AB, Lelystad, The Netherlands.
In this study, 60 pigs with clinical signs of post-weaning multisystemic wasting syndrome (PMWS) from 20 different pig herds and 180 control pigs (without clinical signs of PMWS) were examined to get more insights into the frequencies of porcine circovirus...
Published Jul 2004: Vet Journal. 168(1):41-9.(Abstract)
Postweaning multisystemic wasting syndrome: a review of aetiology, diagnosis and pathology.
Chae C. - Department of Veterinary Pathology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, San 56-1, Shillim-dong, Kwanak-Gu 151-742, Seoul, South Korea.
This review paper concentrates on the aetiology, diagnosis, and pathological aspects of postweaning multisystemic wasting syndrome (PMWS). PMWS was first recognized in Canada in 1996 as a new emerging disease which caused wasting in postweaned pigs. Since...
Published Jul 2004: 18th IPVS Congress, Hamburg, Germany, June 27- July 2, 2004 - Volume 1:12
Evaluation of differences in host susceptibility to PCV2-associated disease
Opriessnig T, Anderson MS, Rothschild MF, Evans RB, Fenaux M, Meng XJ, Halbur PG
Duroc, Landrace, and Large White pigs were inoculated with PCV2 at 5-7 weeks of age in order to compare the impact of PCV2 infection on each breed. The comparison was based on clinical signs and severity of gross and microscopic lesions. Landrace pigs...
Published Jul 2004: 18th IPVS Congress, Hamburg, Germany, June 27- July 2, 2004 - Volume 1:14
PCV2-associated disease following intrauterine infection
Nielsen J, Ladekjær Hansen AS, Bille-Hansen V, Lohse L, Bøtner A
Two PCV2-seropositive gilts were inoculated intranasally with PCV2 at 72 and 92 days of gestation respectively. Piglets born of these two gilts were blood sampled prior colostrum intake and then weekly until 5 weeks of age. They were followed clinically...
Published Jul 2004: 18th IPVS Congress, Hamburg, Germany, June 27- July 2, 2004 - Volume 1:48
Evidence of postweaning multisystemic wasting syndrome (PMWS) in Norway
Brunborg IM, Moldal T; Jonassen CM, Gudmundsson S, Lium B, Bratberg B
First report of PMWS in Norway. The actual prevalence of PCV2-infection in Norway is currently unknown but is suspected to be very high.
Published Jul 2004: 18th IPVS Congress, Hamburg, Germany, June 27- July 2, 2004 - Volume 1:73
First description of porcine circovirus type 2 (PCV2) associated diseases in Bulgaria
Motovski A, Segales J
Eight farms located in various areas of Bulgaria were investigated for the presence of PMWS and PDNS. PMWS was diagnosed in three farms and combined PMWS/PDNS in one farm. All of these farms had high postweaning mortality (>30%) and pigs with typical...
Published Jul 2004: 18th IPVS Congress, Hamburg, Germany, June 27- July 2, 2004 - Volume 1:78
Sow impact on litter mortality in a swine integration system experiencing postweaning multisystemic wasting syndrome (PMWS)
Calsamiglia M, Segales J, Fraile L, Espinal A, Seminati C, Martin M, Mateu E, Domingo M
The litter effect in sows from a PMWS-affected swine integration system was assessed with regards to PCV2 viremia, PCV2 antibody level and parity of sows. Viremic sows had a significantly higher number of dead piglets per litter when compared to non-viremic...
Published Jul 2004: 18th IPVS Congress, Hamburg, Germany, June 27- July 2, 2004 - Volume 1:80
Diagnosis of PMWS by PCR: PCR for PCV2 should not be used for diagnosis of PMWS
Caprioli A, McNeilly F, McNair I, McKillen J, Lagan P, Askin C, Ellis J, Allan G
Blood samples, fecal swabs and tonsil swabs were collected in experimentally PCV2-infected pigs and examined by a non-quantitative PCR for PCV2 DNA. A 25 days post-infection the pigs were euthanized and tissue samples were submitted to histopathological...
Published Jul 2004: 18th IPVS Congress, Hamburg, Germany, June 27- July 2, 2004 - Volume 1:87
Safety of high dose administration of an inactivated adjuvanted PCV2 vaccine in conventional gilts
Reynaud G, Beseme S, Brun A, Charreyre C, Desgouilles S, Jeannin P, Rehbein S
No local or general adverse reaction were observed after one injection of a high dose of a PCV2 vaccine candidate in conventional seropositive gilts. Single vaccination significantly increased already high serological responses to PCV2. This vaccine may...
Published Jul 2004: 18th IPVS Congress, Hamburg, Germany, June 27- July 2, 2004 - Volume 1:88
Safety of a repeated overdose of an inactivated adjuvanted PCV2 vaccine in conventional pregnant gilts and sows
Reynaud G, Brun A, Charreyre C, Desgouilles S, Jeannin P
Ten conventional pregnant gilts and sows with high anti-PCV2 ELISA antibody titers were inoculated 4 weeks and two weeks before expected farrowing with an overdose of an inactivated adjuvanted PCV2 vaccine and compared to 10 control animals inoculated...
