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PMWS Research Archives
Published Aug 2007: Mol Immunol. 2007 Aug 18Immunogenicity of porcine circovirus type 2 capsid protein targeting to different subcellular compartments.
Fan H, Xiao S, Tong T, Wang S, Xie L, Jiang Y, Chen H, Fang L.
Porcine circovirus type 2 (PCV2) is known to be associated with post-weaning multisystemic wasting syndrome (PMWS), an emerging disease in swine. The development of effective vaccines against PCV2 infection has been accepted as an important strategy in...
Published Aug 2007: Research in Veterinary Science Volume 83, Issue 1, August 2007, Pages 12-19
Comparison of two automated spectrophotometric methods for ceruloplasmin measurement in pigs
Martinez-Subiela, S,Tecles, F, Ceron, J.J.
Ceruloplasmin (Cp) determination could provide an objective measure of the health status of an animal and could be used as marker of animal health and welfare (Skinner, 2001) (Skinner, J. G., 2001. Special report. International standardization of acute...
Published Aug 2007: Research in Veterinary Science, 83 (1), p.130-132, Aug 2007
Porcine circovirus type 2 antibody detection in backyard pigs from Mexico City
Ramirez-Mendoza, H, Martinez, C, Mercado, C, Castillo-Juarez, H, Hernandez, J., Segales, J.
PCV2 antibodies have been found in pigs from all continents. However, this finding has been mainly studied in domestic swine reared under intensive production conditions. Mexico City, with a human population over 19 million in 2005, has both urban and...
Published Aug 2007: Virus Res. 2007 Aug 10
Phylogenetic characterization of porcine circovirus type 2 in PMWS and PDNS Korean pigs between 1999 and 2006.
An DJ, Roh IS, Song DS, Park CK, Park BK.
Porcine circovirus type 2 (PCV2) has been associated with several disease outcomes in swine, primarily postweaning multisystemic wasting syndrome (PMWS) and porcine dermatitis nephropathy syndrome (PDNS). Over an 8-year period (1999-2006), we detected...
Published Aug 2007: Can Vet J. 2007 August; 48(8): 811–819.
The emergence of porcine circovirus 2b genotype (PCV-2b) in swine in Canada
Carl A. Gagnon, Donald Tremblay, Peter Tijssen, Marie-Hélène Venne, Alain Houde, and Seyyed Mehdy Elahi
Since late 2004, the swine industry in the province of Quebec has experienced a significant increase in death rate related to postweaning multisystemic wasting syndrome (PMWS). To explain this phenomenon, 2 hypotheses were formulated: 1) the presence...
Published Jul 2007: J Virol Methods. 2007 Jul 17
A new method to identify cell types that support porcine circovirus type 2 replication in formalin-fixed, paraffin-embedded swine tissues.
Pérez-Martín E, Rovira A, Calsamiglia M, Mankertz A, Rodríguez F, Segalés J.
Porcine circovirus type 2 (PCV2) is detected in high amounts within the characteristic microscopic lesions of postweaning multisystemic wasting syndrome (PMWS) affected pigs. In spite of recent advances on disease pathogenesis, the precise cell types...
Published Jun 2007: Vet Immunol Immunopathol. 2007 Jun 15
Ontogeny of systemic cellular immunity in the neonatal pig: Correlation with the development of post-weaning multisystemic wasting syndrome.
Grierson SS, King DP, Tucker AW, Donadeu M, Mellencamp MA, Haverson K, Banks M, Bailey M.
The aetiology of porcine post-weaning multisystemic wasting syndrome (PMWS) is poorly understood. Porcine circovirus type 2 (PCV-2) is an essential component of the experimental disease model for PMWS: however, evidence from experimental and field studies...
Published Jun 2007: J. Gen. Virol., Jun 2007; 88: 1733 - 1737.
Evidence for recombination in natural populations of porcine circovirus type 2 in Hong Kong and mainland China
Ching-Man Ma, Chung-Chau Hon, Tsan-Yuk Lam, Vince Yik-Yeung Li, Creany Ka-Wai Wong, Tulio de Oliveira, and Frederick Chi-Ching Leung
Porcine circovirus type 2 (PCV2) belongs to the family Circoviridae, and is the causative agent of post-weaning multisystemic wasting syndrome (PMWS) in pigs. In this study, phylogenetic analyses of three complete PCV2 genomic sequences from Hong...
Published Jun 2007: Vet Rec. 2007 Jun 2;160(22):751-62
Spatiotemporal patterns and risks of herd breakdowns in pigs with postweaning multisystemic wasting syndrome.
Woodbine KA, Medley GF, Slevin J, Kilbride AL, Novell EJ, Turner MJ, Keeling MJ, Green LE.
A retrospective cohort study of 116 British pig farms was undertaken to investigate the epidemiological risk factors associated with herd breakdowns with postweaning multisystemic wasting syndrome (pmws). Farmers reported the pmws status of their herd...
Published Jun 2007: Research in Veterinary Science, 82 (3), p.299-304, Jun 2007
Sow porcine circovirus type 2 (PCV2) status effect on litter mortality in postweaning multisystemic wasting syndrome (PMWS)
Calsamiglia, M, Fraile, L, Espinal, A, Cuxart, A, Seminati, C, Martin, M, Mateu, E, Segales, J
Previous studies have described a “litter effect” associated with mortality in postweaning multisystemic wasting syndrome (PMWS) affected farms. The main objective of this study was to evaluate litter mortality in different PMWS affected farms and...
Published Jun 2007: Zoonoses and Public Health
Porcine Circovirus 2 Replication in Colostrum-deprived Piglets Following Experimental Infection and Immune Stimulation Using A Modified Live Vaccine against Porcine Respiratory and Reproductive Syndrome Virus
G. M. Allan, A. Caprioli, I. McNair, P. Lagan-Tregaskis, J. Ellis, S. Krakowka, J. McKillen, F. Ostanello, F. McNeilly
Porcine circovirus type 2 (PCV2) infection is now recognized as the major factor in the development of post-weaning multisystemic wasting syndrome (PMWS). Although Koch’s postulates have been fulfilled for PCV2 and PMWS, the severe clinical expression...
Published Jun 2007: Journal of Virology, June 2007, p. 5696-5704, Vol. 81, No. 11
Functional Analysis of cis- and trans-Acting Replication Factors of Porcine Circovirus Type 1
Tobias Steinfeldt, Tim Finsterbusch, and Annette Mankertz
The replication proteins Rep and Rep' of porcine circovirus type 1 (PCV1) are both capable of introducing and resealing strand discontinuities at the viral origin of DNA replication in vitro underlying genome amplification by rolling-circle replication....
Published May 2007: Vet Microbiol. 2007 May 16;122(1-2):72-82. Epub 2007 Jan 23
The involvement of Fas/FasL interaction in porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus co-inoculation-associated lymphocyte apoptosis in vitro.
Chang HW, Jeng CR, Lin CM, Liu JJ, Chang CC, Tsai YC, Chia MY, Pang VF.
Lymphoid depletion of various lymphoid organs is one of the major lesions in pigs suffering from postweaning multisystemic wasting syndrome (PMWS). The co-existence of porcine circovirus type 2 (PCV2) and porcine reproductive and respiratory syndrome...
Published May 2007: Vet Microbiol. 2007 May 16;122(1-2):16-24. Epub 2007 Jan 3
Association of hepatitis E virus (HEV) and postweaning multisystemic wasting syndrome (PMWS) with lesions of hepatitis in pigs.
Martín M, Segalés J, Huang FF, Guenette DK, Mateu E, de Deus N, Meng XJ.
The aim of the study was to determine the presence of swine hepatitis E virus (HEV) RNA and antibodies in postweaning multisystemic wasting syndrome-affected (n=114) and non-affected (n=46) pigs and the possible association with hepatitis lesions. Forty-four...
Published May 2007: Veterinary Research Communications, Volume 31, Number 4, May 2007 , pp. 487-496(10)
Immunogenicity of Empty Capsids of Porcine Circovius Type 2 Produced in Insect Cells
Fan, H.; Ju, C.; Tong, T.; Huang, H.; Lv, J.; Chen, H.
Porcine circovirus type 2 (PCV2), a single-stranded DNA virus, is associated with postweaning multisystemic wasting syndrome (PMWS). ORF2 protein (capsid) of PCV2 was recently demonstrated to be a major immunogenable to induce protection in pigs with...
