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PMWS Research Archives
Published Mar 2008: Vaccine, Volume 26, Issue 11, 10 March 2008, Pages 1488-1499The effect of vaccination against porcine circovirus type 2 in pigs suffering from porcine respiratory disease complex
Vicky Fachinger, Ralf Bischoff, Samir Ben Jedidia, Armin Saalmüller and Knut Elbers
A field study was conducted to investigate the effect of vaccination against porcine circovirus type 2 (PCV2) in pigs suffering from porcine respiratory disease complex (PRDC). A total of 1542 pigs were allocated randomly into two treatment groups at...
Published Mar 2008: Antiviral Research, Volume 77, Issue 3, March 2008, Pages 186-194
Adenovirus-mediated shRNA interference against porcine circovirus type 2 replication both in vitro and in vivo
Zhixin Feng, Ping Jiang, Xianwei Wang, Yufeng Li and Wenming Jiang
Porcine circovirus type 2 (PCV2) is the primary causative agent of an emerging swine disease, postweaning multisystemic wasting syndrome (PMWS), which is responsible for the heavy economic losses in stockbreeding. There are no specific antiviral drugs...
Published Mar 2008: Virus Research, Volume 132, Issues 1-2, March 2008, Pages 201-207
Evidence for recombination between PCV2a and PCV2b in the field
Richard Hesse, Maureen Kerrigan and Raymond R.R. Rowland
Genomic sequence analysis demonstrates that porcine circovirus type 2 (PCV2) isolates are divided into distinct genotypes. Historically, swine herds in the U.S. have been infected with the PCV2a genotype. In 2005, PCV2b was identified in North America...
Published Feb 2008: Vaccine, Volume 26, Issue 8, 20 February 2008, Pages 1063-1071
Porcine circovirus type 2 (PCV2) vaccination of conventional pigs prevents viremia against PCV2 isolates of different genotypes and geographic origins
M. Fort, M. Sibila, A. Allepuz, E. Mateu, F. Roerink and J. Segalés
The efficacy of recently developed porcine circovirus type 2 (PCV2) vaccines has not been tested yet against PCV2 isolates of the two proposed genotypes. In the present work, the efficacy of a subunit vaccine containing PCV2 capsid protein was evaluated...
Published Feb 2008: Res Vet Sci. 2008 Feb;84(1):150-7. Epub 2007 Apr 30
Development and validation of a recombinant capsid protein-based ELISA for detection of antibody to porcine circovirus type 2.
Shang SB, Li YF, Guo JQ, Wang ZT, Chen QX, Shen HG, Zhou JY.
Porcine circovirus type 2 (PCV2) has been recently associated with a number of disease syndromes, especially postweaning multisystemic wasting disease (PMWS). Herein, an alternative indirect enzyme-linked immunosorbent assay (ELISA) for detection of PCV2...
Published Jan 2008: Wei Sheng Wu Xue Bao. 2008 Jan 4;48(1):85-90
Characterization and potential use of truncated PCV2 capsid protein and its polyclonal antibody for diagnosis of PCV2 infections.
Shuai J, Li X, Chen N, Chen X, Fang W.
As porcine circovirus 2 (PCV2) ORF2 encodes the major structural protein (capsid) that is closely related to the pathogenesis, the capsid (Cap) protein could be used as a target antigen for serological analysis. The immunoactivities of the truncated capsid...
Published Jan 2008: J Gen Virol 89 (2008), 177-187; DOI 10.1099/vir.0.83280-0
Antigenic differences among porcine circovirus type 2 strains, as demonstrated by the use of monoclonal antibodies
D. J. Lefebvre, S. Costers, J. Van Doorsselaere, G. Misinzo, P. L. Delputte and H. J. Nauwynck
This study examined whether antigenic differences among porcine circovirus type 2 (PCV-2) strains could be detected using monoclonal antibodies (mAbs). A subtractive immunization protocol was used for the genotype 2 post-weaning multisystemic wasting...
Published Jan 2008: Journal of Virological Methods - Volume 147, Issue 1, January 2008, Pages 61-66
Thermal stability of porcine circovirus type 2 in cell culture
Mark A. O’Dea, Andrew P. Hughes, Linda J. Davies, Jillian Muhling, Ross Buddle and G.E. Wilcox
Received 2 May 2007; revised 25 July 2007; accepted 30 July 2007. Available online 21 September 2007. International trade in pig meat has resulted in some countries placing restrictions on the importation of pig meat, with requirements for cooking...
Published Jan 2008: Journal of Biotechnology - Volume 133, Issue 1, 1 January 2008, Pages 58-64
Expression of the porcine circovirus type 2 capsid protein subunits and application to an indirect ELISA
Pei-Ching Wu, Maw-Sheng Chien, Yu-Yao Tseng, Jiarong Lina Wei-Li Lin, Cheng-Yao Yang and Chienjin Huang
Received 18 April 2007; revised 24 August 2007; accepted 19 September 2007. Available online 2 October 2007. Porcine circovirus type 2 (PCV2) is considered to be associated with post-weaning multisystemic wasting syndrome (PMWS), which is a newly...
Published Dec 2007: New Zealand Veterinary Journal, Volume 55, Number 6, December 2007 , pp. 346-352(7)
Descriptive summary of an outbreak of porcine post-weaning multisystemic wasting syndrome (PMWS) in New Zealand
Neumann, E.J.; Dobbinson, S.S.A.; Welch, E.B.M.; Morris, R.S.
CASE HISTORY: Investigations were conducted to determine the cause of an acute, multi-farm outbreak of porcine respiratory disease that included diarrhoea and subsequent loss of body condition in affected pigs. A definition for post-weaning multisystemic...
Published Dec 2007: Virology - Volume 369, Issue 2, 20 December 2007, Pages 423-430
Enhanced replication of porcine circovirus type 2 (PCV2) in a homogeneous subpopulation of PK15 cell line
Yu Zhu, Adeline Lau, Jennifer Lau, Qiang Jia, Anbu K. Karuppannan and Jimmy Kwang
Received 4 July 2007; revised 27 July 2007; accepted 7 August 2007. Available online 24 September 2007. Post-weaning multi-systemic wasting syndrome (PMWS) has emerged as a major disease that poses a significant threat to the economics of global...
Published Dec 2007: Veterinary Microbiology. Volume 125, Issues 3-4, 15 December 2007, Pages 244-255
Detection of neutralizing antibodies in postweaning multisystemic wasting syndrome (PMWS)-affected and non-PMWS-affected pigs.
Fort M, Olvera A, Sibila M, Segalés J, Mateu E.
Received 2 January 2007; revised 1 June 2007; accepted 5 June 2007. Available online 13 June 2007 The notion that postweaning multisystemic wasting syndrome (PMWS)-affected pigs develop an impaired humoral response against porcine circovirus type...
Published Dec 2007: Virus Genes. 2007 Dec;35(3):619-27. Epub 2007 Sep 13.
Genetic characterization of porcine circovirus type 2 (PCV2) from pigs in high-seroprevalence areas in southeastern China
Jiangbing Shuai, Wei Wei, Xiaoliang Li, Ning Chen, Zhanfeng Zhang, Xueyan Chen and Weihuan Fang
Received: 19 April 2007 Accepted: 16 May 2007 Published online: 13 September 2007 Increasing evidences indicate that porcine circovirus type 2 (PCV2) is the causative agent of the post-weaning multisystemic wasting syndrome (PMWS). In this study, the...
Published Dec 2007: Veterinary Quarterly - Volume 29 (2007), Issue 4
Postweaning multisystemic wasting syndrome (PMWS) in Sweden from an exotic to an endemic disease.
Wallgren P, Belák K, Ehlorsson CJ, Bergström G, Lindberg M, Fossum C, Allan GM, Robertsson JA.
Postweaning multisystemic wasting syndrome (PMWS) is causally associated with porcine circovirus type 2 (PCV2) infection of pigs. PCV2 was first demonstrated in Swedish pigs in 1993, although the virus was almost certainly present in pigs in the country...
Published Nov 2007: J Vet Diagn Invest. 2007 Nov;19(6):668-73.
Temporal distribution of porcine circovirus 2 genogroups recovered from postweaning multisystemic wasting syndrome–affected and –nonaffected farms in Ireland and Northern Ireland
Gordon M. Allan, Francis McNeilly, Michael McMenamy, Irene McNair, Steven G. Krakowka, Sirje Timmusk, Dermot Walls, Maria Donnelly, Donal Minahin, John Ellis, Per Wallgren and Caroline Fossum
Porcine circovirus type 2 (PCV2) is now recognized as the essential infectious component of porcine postweaning multisystemic wasting syndrome (PMWS). PMWS was first recognized in high-status, specific pathogen-free pigs in Canada in 1991 and is now an...
