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PMWS Research Archives

Published Jul 2012: Veterinary Microbiology Volume 158, Issues 1–2, 6 July 2012, Pages 69–81
Effect of Porcine Circovirus Type 2a or 2b on Infection Kinetics and Pathogenicity Of Two Genetically Divergent Strains of Porcine Reproductive and Respiratory Syndrome Virus in the Conventional Pig Model
Tanja Opriessnig, Phillip C. Gauger, Kay S. Faaberg, Huigang Shen, Nathan M. Beach, Xiang-Jin Meng, Chong Wang, Patrick G. Halbur
To determine differences in infection kinetics of two temporally and genetically different type 2 porcine reproductive and respiratory syndrome virus (PRRSV) isolates in vivo with and without concurrent porcine circovirus (PCV) type 2a or 2b infection,...

Published Jul 2012: Veterinary Microbiology, Volume 158, Issues 1–2, 6 July 2012, Pages 95–103
ORF1 but not ORF2 Dependent Differences are Important for in vitro Replication of PCV2 in Porcine Alveolar Macrophages Singularly or Coinfected with PRRSV
Avanti Sinha, Kathy Lin, Michelle Hemann, Huigang Shen, Nathan M. Beach, Carmen Ledesma, Xiang-Jin Meng, Chong Wang, Patrick G. Halbur, Tanja Opriessnig
The objective of this study was to investigate cytokine expression and in vitro replication of porcine circovirus type 2 (PCV2) and porcine reproductive and respiratory syndrome virus (PRRSV) in pulmonary alveolar macrophages (PAMs) emphasizing PCV2 open-reading...

Published Jul 2012: J Gen Virol July 2012 93:1556-1562
Protective Effect of the Maternally Derived Porcine Circovirus Type 2 (PCV2)-Specific Cellular Immune Response in Piglets by Dam Vaccination Against PCV2 Challenge
Yeonsu Oh, Hwi Won Seo, Kiwon Han, Changhoon Park, and Chanhee Chae
The objective of the present study was to evaluate (i) the passive transfer of maternally derived functional porcine circovirus type 2 (PCV2)-specific lymphocytes of seronegative sows immunized with the PCV2 vaccine to newborn piglets and (ii) the functional...

Published Jul 2012: Gen Virol July 2012 93:1548-1555
Single Amino Acid Mutations in the Capsid Switch the Neutralization Phenotype of Porcine Circovirus 2
Dipongkor Saha, David J. Lefebvre, Karen Ooms, Liping Huang, Peter L. Delputte, Jan Van Doorsselaere, and Hans J. Nauwynck
Porcine circovirus 2 (PCV2) is the causative agent of porcine circovirus-associated diseases in pigs. Previously, it was demonstrated that mAbs 16G12, 38C1, 63H3 and 94H8 directed against the PCV2 capsid protein recognize PCV2 strains Stoon-1010 (PCV2a),...

Published Jul 2012: Pig Journal Volume: 67 - June 2012
Benefits of Circovac® Sow Vaccination on Reproductive Parameters: A Field Controlled Trial
L. Maurin-Bernaud, S. Goutebroze, V. Cozette, C. Charreyre, L. Fischer, F. Joisel, T.Vila
A blind, controlled, randomised trial compared the reproductive parameters of 155 sows vaccinated with Circovac® with 54 control non-vaccinated sows. This study was performed on three German farms experiencing severe Porcine Circovirus Disease (PCVD)....

Published Jun 2012: Vet Pathol. 2012 Jun 12. [Epub ahead of print]
Current State of Knowledge on Porcine Circovirus Type 2-Associated Lesions.
Opriessnig T, Langohr I.
Porcine circovirus type 2 (PCV2), a small single-stranded DNA virus, was initially discovered in 1998 and is highly prevalent in the domestic pig population. Disease manifestations associated with PCV2 include postweaning multisystemic wasting disease...

Published Jun 2012: Virol J. 2012 Jun 12;9(1):108. [Epub ahead of print]
Immunization of Mice by Hollow Mesoporous Silica Nanoparticles as Carriers of Porcine Circovirus Type 2 ORF2 Protein.
Guo HC, Feng XM, Sun SQ, Wei YQ, Sun DH, Liu XT, Liu ZX, Luo JX, Yin H.
ABSTRACT: Background Porcine circovirus type 2 (PCV2) is a primary etiological agent of post-weaning multisystemic wasting syndrome (PMWS), which is a disease of increasing importance to the pig industry worldwide. Hollow mesoporous silica nanoparticles...

Published Jun 2012: Journal of Proteomics, Volume 75, Issue 11, 18 June 2012, Pages 3258-3269
Proteomic Analysis of Porcine Alveolar Macrophages Infected With Porcine Circovirus Type 2
Shuang Cheng, Min Zhang, Wentao Li, Yang Wang, Yingyu Liu, Qigai He
Post-weaning multi-systemic wasting syndrome (PMWS), which is primarily caused by porcine circovirus type 2 (PCV2), is an emerging swine immunosuppressive disease. To characterize the interaction between target immune cells and PCV2, the differential...

Published Jun 2012: Vet Rec. 2012 Jun 9;170(23):596. Epub 2012 May 29.
Porcine Circovirus Type 2 Infection Before and During an Outbreak of Postweaning Multisystemic Wasting Syndrome on a Pig Farm in the UK.
Wieland B, Werling D, Nevel A, Rycroft A, Demmers TG, Wathes CM, Grierson S, Cook AJ, Done SH, Armstrong D.
The presence of porcine circovirus type 2 (PCV-2) and other pathogens before and during an outbreak of postweaning multisystemic wasting syndrome (PWMS) in pigs is evaluated in this study. At the time of the outbreak on a large commercial pig farm in...

Published Jun 2012: J Gen Virol June 2012 93:1345-1355
Prevalence and Phylogenetic Analysis of the Current Porcine Circovirus 2 Genotypes after Implementation of Widespread Vaccination Programmes in the USA
Hui-Gang Shen, Patrick G. Halbur, and Tanja Opriessnig
To determine the prevalence of porcine circovirus 2 (PCV2) genotypes in the USA during 2010–2011, 5 years after widespread PCV2 vaccination, serum samples from clinically normal pigs that were PCV2 vaccinated (n=1177), non-vaccinated (n=378) or of...

Published Jun 2012: The Veterinary Journal, Volume 192, Issue 3, June 2012, Pages 385-389
Deletion of the Single Putative N-Glycosylation Site of the Porcine Circovirus Type 2 Cap Protein Enhances Specific Immune Responses by DNA Immunisation in Mice
Jinyan Gu, Ruibin Cao, Yu Zhang, Xue Lian, Hassan Ishag, Puyan Chen
The immunogenicity of a putative N-linked glycosylation site located at amino acids 143–145 (N143YS) of the porcine circovirus 2 (PCV2) Cap protein was investigated. Eukaryotic vectors expressing wild-type PCV2 Cap (pCap) and N-linked glycosylation...

Published May 2012: Veterinary Microbiology, Volume 157, Issues 1–2, 25 May 2012, Pages 13-22
Antigenic Subtyping and Epitopes’ Competition Analysis of Porcine Circovirus Type 2 using Monoclonal Antibodies
Dipongkor Saha, Liping Huang, Eva Bussalleu, David J. Lefebvre, Maria Fort, Jan Van Doorsselaere, Hans J. Nauwynck
Porcine circovirus type 2 (PCV2) strains have been classified into two major genotypes (PCV2a and PCV2b) and 8 genetic clusters: PCV2b-1A to PCV2b-1C and PCV2a-2A to PCV2a-2E. To date, no studies have been performed to antigenically subtype PCV2 strains...

Published May 2012: Veterinary Microbiology, Volume 157, Issues 1–2, 25 May 2012, Pages 61-68
Increased Prevalence of Torque Teno Viruses in Porcine Respiratory Disease Complex Affected Pigs
Lavanya Rammohan, Lin Xue, Chong Wang, Wayne Chittick, Shanthi Ganesan, Sheela Ramamoorthy
The role of swine torque teno sus viruses (TTSuVs) as co-factors in disease syndromes involving porcine circovirus strain 2 (PCV2) and porcine reproductive and respiratory disease syndrome virus (PRRSV) has been a debatable subject. In this study, the...

Published May 2012: Veterinary Microbiology, Volume 157, Issues 1–2, 25 May 2012, Pages 152-163
Infectious Agents Associated with Respiratory Diseases in 125 Farrow-To-Finish Pig Herds: A Cross-Sectional Study
C. Fablet, C. Marois-Créhan, G. Simon, B. Grasland, A. Jestin, M. Kobisch, F. Madec, N. Rose
A study was carried out in 125 farrow-to-finish pig herds to assess the relationships between pathogens involved in respiratory disorders and to relate these findings to clinical signs of respiratory diseases and pneumonia and pleuritis at slaughter....

Published May 2012: J. Virol. May 2012 ; 86:5963; doi:10.1128/JVI.00494-12
Complete Genome Sequence of the Rearranged Porcine Circovirus Type 2
Libin Wen, Kongwang He, Yanxiu Ni, Xuehan Zhang, Bin Li, Xiaomin Wang, Rong li Guo, Zhengyu Yu, Aihua Mao, Junming Zhou, Lixin Lv and Jieyuan Jiang
We first report here the genome sequences of 4 rearranged porcine circovirus type 2 strains, JSTZ, ZJQDH1, ZJQDH2, and JSHM, isolated from porcine sera in China. The complete circular genomes of these isolates are 578, 483, 574, and 772 nucleotides in...

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