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PMWS Research Archives
Published Aug 2007: Can Vet J. 2007 August; 48(8): 811–819.The emergence of porcine circovirus 2b genotype (PCV-2b) in swine in Canada
Carl A. Gagnon, Donald Tremblay, Peter Tijssen, Marie-Hélène Venne, Alain Houde, and Seyyed Mehdy Elahi
Since late 2004, the swine industry in the province of Quebec has experienced a significant increase in death rate related to postweaning multisystemic wasting syndrome (PMWS). To explain this phenomenon, 2 hypotheses were formulated: 1) the presence...
Published Jul 2007: J Virol Methods. 2007 Jul 17
A new method to identify cell types that support porcine circovirus type 2 replication in formalin-fixed, paraffin-embedded swine tissues.
Pérez-Martín E, Rovira A, Calsamiglia M, Mankertz A, Rodríguez F, Segalés J.
Porcine circovirus type 2 (PCV2) is detected in high amounts within the characteristic microscopic lesions of postweaning multisystemic wasting syndrome (PMWS) affected pigs. In spite of recent advances on disease pathogenesis, the precise cell types...
Published Jun 2007: Vet Immunol Immunopathol. 2007 Jun 15
Ontogeny of systemic cellular immunity in the neonatal pig: Correlation with the development of post-weaning multisystemic wasting syndrome.
Grierson SS, King DP, Tucker AW, Donadeu M, Mellencamp MA, Haverson K, Banks M, Bailey M.
The aetiology of porcine post-weaning multisystemic wasting syndrome (PMWS) is poorly understood. Porcine circovirus type 2 (PCV-2) is an essential component of the experimental disease model for PMWS: however, evidence from experimental and field studies...
Published Jun 2007: J. Gen. Virol., Jun 2007; 88: 1733 - 1737.
Evidence for recombination in natural populations of porcine circovirus type 2 in Hong Kong and mainland China
Ching-Man Ma, Chung-Chau Hon, Tsan-Yuk Lam, Vince Yik-Yeung Li, Creany Ka-Wai Wong, Tulio de Oliveira, and Frederick Chi-Ching Leung
Porcine circovirus type 2 (PCV2) belongs to the family Circoviridae, and is the causative agent of post-weaning multisystemic wasting syndrome (PMWS) in pigs. In this study, phylogenetic analyses of three complete PCV2 genomic sequences from Hong...
Published Jun 2007: Vet Rec. 2007 Jun 2;160(22):751-62
Spatiotemporal patterns and risks of herd breakdowns in pigs with postweaning multisystemic wasting syndrome.
Woodbine KA, Medley GF, Slevin J, Kilbride AL, Novell EJ, Turner MJ, Keeling MJ, Green LE.
A retrospective cohort study of 116 British pig farms was undertaken to investigate the epidemiological risk factors associated with herd breakdowns with postweaning multisystemic wasting syndrome (pmws). Farmers reported the pmws status of their herd...
Published Jun 2007: Research in Veterinary Science, 82 (3), p.299-304, Jun 2007
Sow porcine circovirus type 2 (PCV2) status effect on litter mortality in postweaning multisystemic wasting syndrome (PMWS)
Calsamiglia, M, Fraile, L, Espinal, A, Cuxart, A, Seminati, C, Martin, M, Mateu, E, Segales, J
Previous studies have described a “litter effect” associated with mortality in postweaning multisystemic wasting syndrome (PMWS) affected farms. The main objective of this study was to evaluate litter mortality in different PMWS affected farms and to...
Published Jun 2007: Zoonoses and Public Health
Porcine Circovirus 2 Replication in Colostrum-deprived Piglets Following Experimental Infection and Immune Stimulation Using A Modified Live Vaccine against Porcine Respiratory and Reproductive Syndrome Virus
G. M. Allan, A. Caprioli, I. McNair, P. Lagan-Tregaskis, J. Ellis, S. Krakowka, J. McKillen, F. Ostanello, F. McNeilly
Porcine circovirus type 2 (PCV2) infection is now recognized as the major factor in the development of post-weaning multisystemic wasting syndrome (PMWS). Although Koch’s postulates have been fulfilled for PCV2 and PMWS, the severe clinical expression...
Published Jun 2007: Journal of Virology, June 2007, p. 5696-5704, Vol. 81, No. 11
Functional Analysis of cis- and trans-Acting Replication Factors of Porcine Circovirus Type 1
Tobias Steinfeldt, Tim Finsterbusch, and Annette Mankertz
The replication proteins Rep and Rep' of porcine circovirus type 1 (PCV1) are both capable of introducing and resealing strand discontinuities at the viral origin of DNA replication in vitro underlying genome amplification by rolling-circle replication....
Published May 2007: Vet Microbiol. 2007 May 16;122(1-2):72-82. Epub 2007 Jan 23
The involvement of Fas/FasL interaction in porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus co-inoculation-associated lymphocyte apoptosis in vitro.
Chang HW, Jeng CR, Lin CM, Liu JJ, Chang CC, Tsai YC, Chia MY, Pang VF.
Lymphoid depletion of various lymphoid organs is one of the major lesions in pigs suffering from postweaning multisystemic wasting syndrome (PMWS). The co-existence of porcine circovirus type 2 (PCV2) and porcine reproductive and respiratory syndrome...
Published May 2007: Vet Microbiol. 2007 May 16;122(1-2):16-24. Epub 2007 Jan 3
Association of hepatitis E virus (HEV) and postweaning multisystemic wasting syndrome (PMWS) with lesions of hepatitis in pigs.
Martín M, Segalés J, Huang FF, Guenette DK, Mateu E, de Deus N, Meng XJ.
The aim of the study was to determine the presence of swine hepatitis E virus (HEV) RNA and antibodies in postweaning multisystemic wasting syndrome-affected (n=114) and non-affected (n=46) pigs and the possible association with hepatitis lesions. Forty-four...
Published May 2007: Veterinary Research Communications, Volume 31, Number 4, May 2007 , pp. 487-496(10)
Immunogenicity of Empty Capsids of Porcine Circovius Type 2 Produced in Insect Cells
Fan, H.; Ju, C.; Tong, T.; Huang, H.; Lv, J.; Chen, H.
Porcine circovirus type 2 (PCV2), a single-stranded DNA virus, is associated with postweaning multisystemic wasting syndrome (PMWS). ORF2 protein (capsid) of PCV2 was recently demonstrated to be a major immunogenable to induce protection in pigs with...
Published May 2007: This Article
Structure-Dependent Modulation of Alpha Interferon Production by Porcine Circovirus 2 Oligodeoxyribonucleotide and CpG DNAs in Porcine Peripheral Blood Mononuclear Cells
Frida Hasslung Wikström, Brian M. Meehan, Mikael Berg, Sirje Timmusk, Josefine Elving, Lisbeth Fuxler, Mattias Magnusson, Gordon M. Allan, Francis McNeilly, and Caroline Fossum
DNA sequences containing CpG motifs are recognized as immunomodulators in several species. Phosphodiester oligodeoxyribonucleotides (ODNs) representing sequences from the genome of porcine circovirus type 2 (PCV2) have been identified as potent inducers...
Published Apr 2007: Vet Microbiol. 2007 Apr 15;121(3-4):215-24. Epub 2006 Dec 9
Protection of pigs against post-weaning multisystemic wasting syndrome by a recombinant adenovirus expressing the capsid protein of porcine circovirus type 2.
Wang X, Jiang P, Li Y, Jiang W, Dong X.
Following a description of the several-step process necessary for the conversion of production system to batch farrowing, the authors addresses the advantages and disadvantages of such a management system. As primary advantage features the implementation...
Published Apr 2007: Virus Genes, Volume 34, Number 2, April 2007 , pp. 199-204(6)
Expression of porcine circovirus 2 ORF2 gene requires codon optimized E. coli cells
Trundova, Maria; Celer, Vladimir
Expression and purification of whole and nuclear localization signal (NLS) deleted ORF2 capsid protein of porcine circovirus 2 (PCV2) is demonstrated in the present study. Gene coding for both protein forms were cloned into pDest17 vector and expressed...
Published Apr 2007: Res Vet Sci. 2007 Apr 27;
Development and validation of a recombinant capsid protein-based ELISA for detection of antibody to porcine circovirus type 2.
Shang SB, Li YF, Guo JQ, Wang ZT, Chen QX, Shen HG, Zhou JY.
Porcine circovirus type 2 (PCV2) has been recently associated with a number of disease syndromes, especially postweaning multisystemic wasting disease (PMWS). Herein, an alternative indirect enzyme-linked immunosorbent assay (ELISA) for detection of PCV2...
