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PMWS Research Archives

Published May 2012: Acta Vet Scand. 2012; 54(1): 29. Published online 2012 May 3
Detection of Porcine Circovirus Genotypes 2a and 2b in Aborted Foetuses from Infected Swine Herds in the State of São Paulo, Brazil
Alessandra MMG de Castro, Taís F Cruz, Vanessa R Salgado, Tatiana M Kanashiro, Karen L Ferrari, João P Araujo, Jr, Paulo E Brandão and Leonardo J Richtzenhain
Background Porcine circovirus type 2 (PCV2) has been associated with several disease complexes, including reproductive failure. The aim of this study was to identify the subtypes of PCV2 that are associated with reproductive failure in pigs from the...

Published Apr 2012: J. Virol. April 2012 ; 86:4716; doi:10.1128/JVI.00268-12
Complete Genome Sequence of a Highly Prevalent Porcine Circovirus 2 Isolated from Piglet Stool Samples in China
Bin Li, Junjie Ma, Yanling Liu, Libin Wen, Zhengyu Yu, Yanxiu Ni, Xuehan Zhang, Junming Zhou, Rongli Guo, Xiaomin Wang, Zhixin Feng, Yiyi Hu, Lixin Lv and Kongwang He
Porcine circovirus type 2 (PCV2) is the etiologic agent of porcine circovirus-associated disease. Here, we first report the complete genome sequence of PCV2 strain JSTZ, which was isolated from piglet stool samples and is highly prevalent in China. It...

Published Apr 2012: Virology, Volume 426, Issue 1, 25 April 2012, Pages 66-72
Reactive Oxygen Species Regulate the Replication of Porcine Circovirus Type 2 via NF-κB Pathway
Xingxiang Chen, Fei Ren, John Hesketh, Xiuli Shi, Junxian Li, Fang Gan, Kehe Huang
Intracellular redox state has been suggested to have various effects on the replication of different viruses within host cells. The aim of the present study was to investigate the influence of reactive oxygen species (ROS) on replication of porcine circovirus...

Published Apr 2012: FEMS Microbiol Lett. 2012 Apr 11. [Epub ahead of print]
Attenuated Streptococcus equi ssp. Zooepidemicus as a Bacterial Vector for Expression of Porcine Circovirus Type 2 Capsid Protein.
Wei Z, Fu Q, Liu X, Chen Y.
Porcine circovirus type 2 (PCV2) infection and other concurrent factors is associated with post-weaning multisystemic wasting syndrome (PMWS) which is becoming a major problem for the swine industry worldwide. Coinfection of Streptococcus equi ssp. zooepidemicus...

Published Apr 2012: Journal of Virological Methods, In Press, Uncorrected Proof, Available online 3 April 2012
Development of Multiplex PCR for Simultaneous Detection of Six Swine DNA and RNA Viruses
Xin-Gang Xu, Guang-Da Chen, Yong Huang, Li Ding, Zhao-Cai Li, Ching-Dong Chang, Chi-Young Wang, De-Wen Tong, Hung-Jen Liu
Uniplex and multiplex reverse transcription-polymerase chain reaction (RT-PCR) and PCR protocols were developed and evaluated subsequently for its effectiveness in detecting simultaneously single and mixed infections in swine. Specific primers for three...

Published Apr 2012: International Journal of Biological Macromolecules, Volume 50, Issue 3, 1 April 2012, Pages 713-719
Immunomodulatory and Antioxidant Effects of Carboxymethylpachymaran on the Mice Infected with PCV2
Ying-Yi Wei, Ting-Jun Hu, Zi-Jie Su, Yun Zeng, Xiao-Jie Wei, Shu-Xia Zhang
The objective of the current study is to investigate the protective effect of carboxymethylpachymaran (CMP) on the immune system of mice via multiple infections with porcine circovirus type 2 (PCV2). The in vivo results showed that CMP administration...

Published Mar 2012: Acta Vet Scand. 2012 Mar 26;54(1):17. [Epub ahead of print]
PCV2-DNA in Formalin-Fixed and Paraffin Embedded Lymph Nodes of Wild Boar (Sus scrofa ssp. scrofa): One Sampling Approach for two Laboratory Techniques
Morandi F, Panarese S, Verin R, Ostanello F, Benazzi C, Sarli G.
Superficial inguinal lymph nodes from 72 wild boars examined in a previous immunohistochemical (IHC) study on porcine circovirus type 2 (PCV2) were selected for a PCV2 polymerase chain reaction (PCR) analysis. Four of these lymph nodes were PCV2-IHC strongly...

Published Mar 2012: BMC Veterinary Research 2012, 8:32 (22 March 2012)
Serum Protein Profiles as Potential Biomarkers for Infectious Disease Status in Pigs
Miriam GJ Koene, Han A Mulder, Norbert Stockhofe-Zurwieden, Leo Kruijt and Mari A Smits
Background In veterinary medicine and animal husbandry, there is a need for tools allowing the early warning of diseases. Preferably, tests should be available that warn farmers and veterinarians during the incubation periods of disease and before the...

Published Mar 2012: Virology Journal 2012, 9:68 (15 March 2012)
Patterns and Influencing Factor of Synonymous Codon Usage in Porcine Circovirus
Xin-sheng Liu, Yong-guang Zhang, Yu-zhen Fang, Yong-lu Wang
Background Analysis of codon usage can reveal much about the molecular evolution of the viruses. Nevertheless, little information about synonymous codon usage pattern of porcine circovirus (PCV) genome in the process of its evolution is available. In...

Published Mar 2012: Virus Research, Volume 164, Issues 1–2, March 2012, Pages 1-3
Spread like a Wildfire—The Omnipresence of Porcine Circovirus Type 2 (PCV2) and its ever-expanding Association with Diseases in Pigs
Xiang-Jin Meng
The discovery of porcine circovirus type 2 (PCV2) in 1998 initiated intensive research on arguably the most economically important pathogen facing the global swine industry today. PCV2 infection is now widespread worldwide, and increasing numbers of disease...

Published Mar 2012: Virus Research, Volume 164, Issues 1–2, March 2012, Pages 10-19
Porcine Circovirus Type 2 (PCV2) Infections: Clinical Signs, Pathology and Laboratory Diagnosis
Joaquim Segalés
Clinical signs and pathological features are still the corner-stones to suspect and diagnose overt disease associated with PCV2 infection. The clinico-pathological scope of this viral infection has been expanded over time. From the initial description...

Published Mar 2012: Virus Research, Volume 164, Issues 1–2, March 2012, Pages 54-60
Molecular Interactions of Porcine Circoviruses Type 1 and Type 2 with its Host
Annette Mankertz
This review discusses the molecular interaction of proteins encoded by porcine circoviruses type 1 (PCV1) and type 2 (PCV2) with respect to the putative role for disease induction. Besides protein:protein interactions also proteins binding to PCV DNA...

Published Mar 2012: Virus Research, Volume 164, Issues 1–2, March 2012, Pages 68-77
Genetic Variation of Porcine Circovirus Type 2 (PCV2) and its Relevance to Vaccination, Pathogenesis and Diagnosis
Benjamin R. Trible, Raymond R.R. Rowland
Porcine circovirus-associated disease (PCVAD) encompasses a group of complex, multi-factorial syndromes, which are dependent on infection with porcine circovirus type 2 (PCV2). Current strains of PCV2 circulating in the field are classified into two groups,...

Published Mar 2012: Virus Research, Volume 164, Issues 1–2, March 2012, Pages 78-89
Epidemiology and Transmission of Porcine Circovirus Type 2 (PCV2)
Nicolas Rose, Tanja Opriessnig, Béatrice Grasland, André Jestin
PCV2 has been highly prevalent in the pig population for decades, prior to the emergence of associated clinical disease manifestations that severely affected the pig production worldwide in the late 90s. PCV2 can be further subdivided into several genotypes....

Published Mar 2012: Virus Research, Volume 164, Issues 1–2, March 2012, Pages 33-42
Efficacy and Future Prospects of Commercially Available and Experimental Vaccines against Porcine Circovirus Type 2 (PCV2)
Nathan M. Beach, Xiang-Jin Meng
Porcine circovirus type 2 (PCV2) is the causative agent of an economically significant collection of disease syndromes in pigs, now known as porcine circovirus associated diseases (PCVADs) in the United States or porcine circovirus diseases (PCVDs) in...

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