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PMWS Research Archives
Published Feb 2011: Virology, 410 (1), p.248, Feb 2011ORF3 of Porcine Circovirus 2 Enhances the in vitro and in vivo Spread of the of the Virus
Karuppannan, Anbu K., Kwang, Jimmy
The ORF3 protein of the pathogenic porcine circovirus 2 (PCV2) causes apoptosis of the virus-infected cells. In PCV2-infected piglets, ORF3 induces B and CD4 T lymphocyte depletion and lymphoid organ destruction and the ORF3-deficient PCV2 is attenuated...
Published Feb 2011: Research in Veterinary Science, 90 (1), p.168, Feb 2011
Genetic Typing of Porcine Circovirus Type 2 (PCV-2) Isolates from Slovakia
Vlasakova, M. , Jackova, A. , Vilcek, S.
Of 120 clinical specimens obtained from pigs bred on 28 PMWS-affected farms in Slovakia, porcine circovirus type 2 (PCV-2) was detected by single PCR in 77 samples. A short 224 bp fragment of ORF2 was used for preliminary grouping of isolates by phylogenetic...
Published Feb 2011: Pig Journal Volume: 64
Weaning Weight Improvements Following PCV2 Sow Vaccination
N. BRONS, R. NETO, V. THIAS, F. JOISEL, S. LONGO
Exposure to Porcine Circovirus type 2 (PCV2) occurs very early in the life of a pig andmay compromise the pig’s ability to respond to infectious agents (viral and bacterial) when exposed to PCV2 without the presence of protectivematernally derived immunity....
Published Feb 2011: Pig Journal Volume: 64
Experiences with Porcine Circovirus Type 2 (PCV2) Vaccination in North America and Europe
P. Maass, D. Strachan
Herd breakdowns with Porcine Circovirus Disease (PCVD) appeared to escalate to epizootic proportions in North America from 2004, following a similar pattern to that seen in Europe and the rest of the world since 1996. Fortunately, great advances had beenmade...
Published Jan 2011: Veterinary Microbiology Volume 147, Issues 3-4, 27 January 2011, Pages 329-339
Longitudinal Study of Respiratory Infection Patterns of Breeding Sows in Five Farrow-to-Finish Herds
C. Fablet, C. Marois, G. Kuntz-Simon, N. Rose, V. Dorenlor, F. Eono, E. Eveno, J.P. Jolly, L. Le Devendec, V. Tocqueville, S. Quéguiner, S. Gorin, M. Kobisch, F. Madec
A longitudinal study was carried out in five French farrow-to-finish herds differently affected by respiratory diseases to describe the carrying and infection patterns of batches of sows to various respiratory pathogens during gestation and lactation....
Published Jan 2011: Virology Journal 2011, 8:37
Development of an in situ Assay for Simultaneous Detection of the Genomic and Replicative Forms of PCV2 using Padlock Probes and Rolling Circle Amplification
Sara Henriksson, Anne-Lie Blomstrom, Lisbeth Fuxler, Caroline Fossum, Mikael Berg and Mats Nilsson
Background In this study we utilized padlock probes and rolling circle amplification as a mean to detect and study the replication of porcine circovirus type 2 (PCV2) in cultured cells and in infected tissue. Porcine circovirus type 2 is a single-stranded...
Published Jan 2011: Transboundary and Emerging Diseases Jan 2011
Prolonged Detection of PCV2 and Anti-PCV2 Antibody in Oral Fluids Following Experimental Inoculation
J. R. Prickett, J. Johnson, M. P. Murtaugh, S. Puvanendiran, C. Wang, J. J. Zimmerman and T. Opriessnig
The onset, level and duration of PCV2 and anti-PCV2 antibody in oral fluid were evaluated using samples collected from experimentally inoculated pigs for 98 days post-inoculation (DPI). Pigs (n = 24) were obtained at 3 weeks of age and randomly...
Published Jan 2011: Veterinary Microbiology, Volume 147, Issues 1-2, 10 January 2011, Pages 49-58
Effect of an Interferon-Stimulated Response Element (ISRE) Mutant of Porcine Circovirus Type 2 (PCV2) on PCV2-Induced Pathological Lesions in a Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Co-Infection Model
S. Ramamoorthy, T. Opriessnig, N. Pal, F.F. Huang, X.J. Meng
Porcine circovirus type 2 (PCV2) is the primary causative agent of porcine circovirus-associated diseases (PCVAD) in swine. Coinfections of PCV2 with other swine pathogens increase the severity of PCVAD. Induction of proinflammatory cytokines by coinfecting...
Published Jan 2011: Microbiology and Immunology Jan 2011
A Candidate Inactivated Chimeric Vaccine PCV1-2 Constructed Based on PCV1 and PCV2 Isolates Originated in China and the Evaluation in Conventional Pigs for its Protective Efficacy against PCV2 Infection
Liu Xujie, Wang Xiaobo, Song Yi, Fan Jing, Gao Song, Liu Xiufan
A chimeric PCV1-2 clone containing the PCV2 capsid gene cloned into the backbone of the nonpathogenic PCV1 genome was recently generated based on the PCV2 and PCV1 strains isolated in China. Furthermore, the efficacy of this available candidate inactivated...
Published Jan 2011: J Comp Pathol. Volume 144, Issue 1, January 2011, Pages 63-69
Characterization of Necrotizing Lymphadenitis Associated with Porcine Circovirus Type 2 Infection.
Galindo-Cardiel I, Grau-Roma L, Pérez-MaÃllo M, Segalés J.
Necrotizing lymphadenitis is observed in approximately 2% of pigs affected by post-weaning multisystemic wasting syndrome (PMWS). The pathogenesis of the lesion has been linked to apoptosis induced by porcine circovirus type 2 (PCV2). The aim of the present...
Published Jan 2011: Journal of Virological Methods, Volume 171, Issue 1, January 2011, Pages 26-33
Development of a Blocking ELISA for detection of Serum Neutralizing Antibodies against Porcine Circovirus Type 2
Liping Huang, Yuehua Lu, Yanwu Wei, Longjun Gua and Changming Liu
A monoclonal antibody (Mab)-based blocking ELISA was developed for the detection of serum neutralizing antibodies to porcine circovirus type 2 (PCV2). The Mab with neutralizing activity, which was produced by immunizing a recombinant capsid protein of...
Published Dec 2010: Virol J. 2010 Dec 31;7(1):374. [Epub ahead of print]
Rapid detection of porcine circovirus type 2 using a TaqMan-based real-time PCR
Zhao K, Han F, Zou Y, Zhu L, Li C, Xu Y, Zhang C, Tan F, Wang J, Tao S, He X, Zhou Z, Tang X.
Porcine circovirus type 2 (PCV2) and the associated disease postweaning multisystemic wasting syndrome (PMWS) have caused heavy losses in global agriculture in recent decades. Rapid detection of PCV2 is very important for the effective prophylaxis and...
Published Dec 2010: Acta Vet Hung. 2010 Dec;58(4):483-98.
Distribution of Porcine Circovirus 2 Cap Antigen in the Lymphoid Tissue of Pigs Affected by Postweaning Multisystemic Wasting Syndrome.
Becskei Z, Aleksić-Kovačević S, Rusvai M, Balka G, Jakab C, Petrović T, Knežević M.
The lymphatic organs of 50 pigs from a total of eight farms located at different sites in the epizootiological region of North Bačka County were studied to obtain data on the prevalence of circoviral infections in Serbia. All of the pigs examined...
Published Dec 2010: BMC Veterinary Research 2010, 6:59
Spread of Porcine Circovirus Associated Disease (PCVAD) in Ontario (Canada) Swine Herds: Part I. Exploratory Spatial Analysis
Zvonimir Poljak, Catherine E Dewey, Thomas Rosendal, Robert M Friendship, Beth Young and Olaf Berke
Background The systemic form of porcine circovirus associated disease (PCVAD), also known as postweaning multisystemic wasting syndrome (PMWS) was initially detected in the early 1990s. Starting in 2004, the Canadian swine industry experienced...
Published Dec 2010: Veterinary Record 2010; Volume 167, Issue 24 167:940-941
Changes in Age at Dagnosis of PMWS in Pigs in Spain, 1998 to 2008
Segalés J, Cortey M.
