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Antimicrobial Reduces Risk of PED Virus Infection in Young Pigs

13 October 2014

US - An approved liquid antimicrobial has been shown to reduce the risk of porcine epidemic diarrhoea (PED) virus infection through contaminated feed, according to recently published research.

Since its initial detection in May 2013, PED virus (PEDV) has spread rapidly throughout the US swine industry.

Recently, contaminated feed was confirmed as a vehicle for PEDV infection of naïve piglets. according to Scott Dee of Pipestone Veterinary Services and co-authors there and at South Dakota State University.

Their research, published in BMC Veterinary Research, provides in vivo data supporting the ability of a liquid antimicrobial product to reduce this risk, they report.

Sal CURB® (Kemin Industries, Des Moines, IA, USA) is an FDA-approved liquid antimicrobial used to control Salmonella contamination in poultry and swine diets. To test its effect against PEDV, Sal CURB-treated feed was spiked with a stock isolate of PEDV (Ct = 25.22), which PEDV-naïve piglets were allowed to ingest via natural feeding behaviour (ad libitum) for a 14-day period.

For the purpose of a positive control, a separate group of piglets was allowed to ingest non-treated (Sal CURB-free) feed also spiked with stock PEDV (Ct = 25.22). A negative control group received PEDV-free feed.

Clinical signs of PEDV infection (vomiting and diarrhoea) and viral shedding in faeces were observed in the positive control group two to three days post-consumption of non-treated feed. In contrast, no evidence of infection was observed in pigs fed Sal CURB-treated feed or in the negative controls throughout the 14-day study period.

In addition, the Sal CURB-treated feed samples had higher (p< 0.0001) mean PEDV Ct values than samples from the positive control group.

These data provide proof of concept that feed treated with Sal CURB can serve as a means to reduce the risk of PEDV infection through contaminated feed, concluded Dee and co-authors.

Furthermore, they add, the results from the positive control group provide additional proof of concept regarding the ability of contaminated feed to serve as a risk factor for PEDV infection of naïve piglets.


Dee S., C. Neill, T. Clement, J. Christopher-Hennings and E. Nelson 2014. An evaluation of a liquid antimicrobial (Sal CURB®) for reducing the risk of porcine epidemic diarrhea virus infection of naïve pigs during consumption of contaminated feed. BMC Veterinary Research. 10:220. doi:10.1186/s12917-014-0220-9

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