- news, features, articles and disease information for the swine industry

ThePigSite Quick Disease Guide

Use the above box to quickly switch to another disease

Swine Influenza Virus (SI), Flu

Related Products:
Swine influenza is caused by a number of closely related influenza A viruses that are noted for their ability to change their antigenic structure and create new strains.

Each serotype is identified by surface proteins referred to as "H" and "N". The three common strains that affect the pig are described as H1 N1, H1 N2 and H3 N2. There are also different strains within these serotypes with differing pathogenicity (capacity to produce disease).

The incubation period of the disease is very short, as little as 12-48 hours and the onset is usually rapid and dramatic.

It is virtually impossible to maintain a population of pigs that is influenza virus free.

SI in large herds may become endemic with intermittent bouts of disease and infertility and different strains may also sequentially infect the herd. Immunity to influenza viruses is often short lived (6 months) and the immunity profile in the breeding herd varies considerably with time.



  • It would be unusual to see any signs of swine flu in the sucking pig unless disease entered the herd for the first time.
  • Colostrum may prevent infection during the sucking period.
  • Coughing.
  • Pneumonia.
  • Fever.
  • High temperatures which cause abortions.
  • Widespread coughing.
  • Pneumonia
When the virus first enters the herd two or three animals may be observed sick for the first two days, followed by:
  • A rapid explosive outbreak of inappetence and clinically very ill pigs.
  • The effects on the reproductive system follow the sudden onset of a rapid spreading respiratory disease with coughing, pneumonia, fevers and inappetence.
  • Acute respiratory distress persists over a period of 7-10 days (depending on the amount of contact between groups of sows).
At a herd level the following may also be seen:
  • A sudden and rapid onset of acute illness in sows.
  • Coughing and pneumonia spreading rapidly.
  • A return to clinical normality over 7-10 days.
  • Delayed returns to heat after weaning.
  • Increased repeats at 21 days.
  • Increased repeats outside the normal cycle.
  • Increased numbers of sows coming through not in-pig.
  • Increased numbers of abortions, particularly late term.
  • Increased numbers of stillbirth rates and slow farrowings.
  • Premature farrowings.
  • Occasionally an increase in mummified pigs.
  • During the phases of high temperatures other diseases present in the herd may be triggered off. A typical example would be an increase in abortions associated with leptospira infection.
Weaners & Growers

Acute disease:

  • Classically the pigs suddenly become prostrate.
  • Breathing heavily.
  • Severe coughing.
  • Most of them look as if they are going to die but most of them survive without treatment unless the herd already has a respiratory disease problem.
  • SI causes severe pneumonia on its own but when it is combined with other infections such as App, EP and PRRS an intractable chronic respiratory disease syndrome can develop. Severely affected individuals or groups of pigs are therefore best given antibiotic cover to prevent secondary pneumonias developing.
Endemic disease:
  • Here the virus remains in the herd, affecting small groups of pigs often weaners. It may be responsible for continuing respiratory diseases with symptoms as in acute disease but less dramatic.

Causes / Contributing factors

SI can be introduced by:
  • Infected animals including people, pigs and birds.
  • Carrier pigs.
  • Probably on the wind although this has not been proved.
  • Birds particularly water fowl, are reservoirs of infection.
  • Secondary bacterial infections.
  • Fluctuating temperatures.
  • Stress.
  • Wet bedding and floor surfaces.
  • Poor nutrition.


This can often be made reliably on clinical grounds with acute disease because there are no other diseases that are so dramatic in their onset and clinical effects. No other disease affects so many pigs so quickly. Blood samples taken at the time of onset of disease from affected sows and repeated 2-3 weeks later show rising levels of antibody to the specific virus. SIV can be readily grown from nasal and throat swabs and identified in the laboratory. This is often the best approach to confirm the diagnosis.

In acute disease the spread is so dramatic across all ages that little else can be confused with it. In endemic disease however differentiation from other viral infections can be difficult, but PRRS, PRCV, AD and also erysipelas should be considered.


Which sample to take for swine influenza

When testing for SIV, it’s important to choose the correct sample and testing method. So which sample is best?

For detection of the presence of the virus, real-time PCR is used. The PCR test can also be used to identify the subtype of the virus.

Samples taken for PCR are

  • Nasal swabs: used to diagnose clinical cases as well as for herd monitoring. The samples can then also be used for next generation sequencing for identification of the virus strain.
  • Oral fluids: for SIV detection at the pen level for prognostic profiling. This is helpful to monitor disease at the herd level and diagnose clinical cases at the pen level.

For detection of antibodies, ELISA tests are used. The main samples taken for ELISA are whole blood or serum. ELISA tests are used for herd level monitoring, especially for eradication purposes or to have a general idea about the health status of the herd.

Timeframe for detection

Short timeframe after infection, oral fluids extends the detection time

PCR on nasal swabs (blue) for the detection of the presence of the virus gives information on the infection status of an individual pig. SIV viremia is very short lived (0-5 days) and clinical signs on a farm may not be clear. If the veterinarian gets called in too late, you may miss the moment to capture the virus. If that happens and the lab runs a PCR, it will come back with negative results and you will not know if the virus has been present in the herd.

Oral fluid sampling (yellow) extends the period to catch the virus to up to 15 days as the sample originates from a larger number of animals. Oral fluids can be sampled more easily, and it can be done by the farmer. So even if the farmer has a suspicion, he or she can obtain the oral fluid sample, send it to the lab and plan next steps with the veterinarian.

Detection of antibody response for swine influenza

If for any reason you have missed the acute clinical phase, use the antibody test. It’ll tell you if there has been an infection.

For more information about diagnostic solutions for SIV, click here.

Further Reading

Click on the links below to find out more about this disease, including treatment, management control and prevention information. The top link is the main article on this disease.