Quest for New Vaccine Strategies against CSF

Efficient live attenuated vaccines against CSFV exist and are routinely used only in endemic countries. The ability of these vaccines to replicate in the host, even at very low rates, makes it extremely difficult to distinguish vaccinated from infected animals, favouring a restricted policy regarding vaccination against CSFV in non-endemic countries. There is a clear need for efficient and safer marker vaccines to assist in the control of future CSF outbreakss.

The project entitled “New vaccine strategies against CSFV. Study of the mechanisms of viral immunopathogenicity” will permit studying different mechanisms of protection against CSFV for developing new vaccination strategies and rapid infection diagnostic methods.

The main purposes of this project are:

• Development of new vaccine strategies against CSFV, based on the use of dendrimeric peptides combining B-cell and T-cell epitopes and in DNA vaccines.
• Characterization of the immunological mechanisms associated with protection against disease.
• Study of the mechanisms of viral pathogenicity in pigs infected with strains of different virulence.
• Development of new strategies based on immunological and molecular techniques for the rapid diagnosis of CSFV.
• Studies of viral evolution in strains isolated from pigs during 20 years of circulation of the virus in the field.

The CReSA’s team involved in the development of the project is made of: Dr. Mariano Domingo, Dr. Llilianne Ganges, Dr. Lorenzo Fraile, Dr. Francesc Xavier Abad, Iván Galindo and Joan Tarradas.

Further Reading

-

Find out more information on Classical Swine Fever Virus (CSF) by clicking here.

ThePigSite News Desk

Sign up for our
regular news updates

Related news items:

•    FMD NEWS: China Resolves FMD Issue
•    First Trivalent Swine Flu Vaccine with H1N2 Launched
•    Irish Pig Herds Declared Practically Aujeszky-Free
•    Merial To Merge With Intervet/Schering-Plough
•    Pig Vaccine May Eliminate Fatal Human Brain Disorder

Related News Categories: Pig Health

Sign up for our
regular news updates

More of the latest Pig Industry News

•   Pfizer Welcomes Agreement with Elanco on Divested Assets
•   Ensuring Sustainable Livestock Production
•   Pork Commentary: Markets Take a Rest
•   Mistreatment of Migrant and Agency Workers
•   Recession Impacts Consumer Buying Habits
•   EU Pig Prices: Unchanged Quotations Throughout EU
•   Feed Manual to be Launched at Cancun Congress
•   Weekly Outlook: Month-end USDA Reports
•   Market Preview: Federal Market Oversight Likely
•   CME: Predictor of Fed Cattle/Market Hog Prices