A research paper by T.A. Wyatt, J.H. Sisson, S.G. Von Essen, J.A. Poole and D.J. Romberger published in the European Respiratory Journal shows dust extracts from swine confinement facilities stimulate the production of proinflammatory cytokines in bronchial epithelial cells, including interleukin-8 (IL-8).

The researchers from the Deptpartment of Internal Medicine, Pulmonary, Critical Care, Sleep & Allergy Section, University of Nebraska Medical Center, and Omaha Veterans Affairs Medical Center say that because IL-8 is capable of blocking beta-agonist-stimulated increases in cilia beating, which impacts mucociliary clearance, they hypothesized that hog barn dust exposure might alter cilia responses to stimulation.

To test this hypothesis, ciliated bovine bronchial epithelial cell cultures were exposed to hog barn dust extract (HDE) and cilia beat frequency (CBF) assayed.

An elevation in baseline CBF was observed. This effect appeared to be independent of endotoxin, but dependent upon nitric oxide. HDE also stimulated nitric oxide production in bronchial epithelial cells; however, stimulation of cilia beating by a beta-agonist did not occur in cells pre-exposed to HDE.

These data demonstrate that hog barn dust can alter normal stimulation of cilia, suggesting a mechanism for the abrogation of stimulated increases in mucociliary clearance in response to inhaled dust exposure.

Further Reading

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