Aptimmune launches industry’s first inactivated mucosal IAV-S

Aptimmune Biologics introduces the industry’s first inactivated mucosal influenza A virus in swine (IAV-S) vaccine administered via nasal spray.
calendar icon 17 November 2017
clock icon 3 minute read

Aptimmune’s IAV-S vaccine utilizes the BARRICADE™ proprietary vaccine formulation that gives swine producers and veterinarians a completely different approach to conventional inactivated injectable and live virus vaccines for safely preventing and managing respiratory disease.

This inactivated mucosal vaccine is a new class of vaccines that mitigates respiratory disease at the point of entry. BARRICADE™ IAV-S combines three core components essential for effective disease protection: First, contemporary influenza type A antigen relevant for current application. Second, a powerful and safe immune-stimulating adjuvant. Lastly, Aptimmune’s proprietary nanoparticles deliver the vaccine payload to immune cells at the mucosal surface.

Jessica Seate, DVM, professional services veterinarian for Aptimmune Biologics, explained the way in which the BARRICADE™ IAV-S works:

BARRICADE™ IAV-S has shown to target immune cells at the respiratory surface, where the pig is naturally exposed to infection. BARRICADE’S™ revolutionary approach provides veterinarians and producers the opportunity to produce an IAV-S vaccine which may contain up to five contemporary influenza type A strains, such as H1N1, H1N2 and H3N2.

This inactivated-virus mucosal vaccine with its needleless, intranasal administration is safe to pigs, people, and is PQA-Plus friendly, making it an effective alternative to conventional IAV-S vaccines.

Aaron Gilbertie, Aptimmune CEO, commented on the successes of the BARRICADE™ technology so far:

Our BARRICADE™ PRRS vaccine continues to perform well on swine farms across the country, under some of the toughest disease conditions, and has validated our collaborative innovation model for developing and manufacturing custom mucosal vaccines. And because our PRRS and IAV-S vaccines utilize the same BARRICADE™ technology, they can be combined and administered together to prevent these two important diseases when appropriate.

For more information Aptimmune’s inactivated mucosal IAV-S vaccine, click here

Aptimmune news release

Emily Houghton

Editor, The Pig Site

Emily Houghton is a Zoology graduate from Cardiff University and was the editor of The Pig Site from October 2017 to May 2020. Emily has worked in livestock husbandry, and has written, conducted and assisted with research projects regarding the synthesis of welfare and productivity of free-range food species.

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