Antimicrobial Reduces Risk of PED Virus Infection in Young Pigs

US - An approved liquid antimicrobial has been shown to reduce the risk of porcine epidemic diarrhoea (PED) virus infection through contaminated feed, according to recently published research.
calendar icon 13 October 2014
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Since its initial detection in May 2013, PED virus (PEDV) has spread rapidly throughout the US swine industry.

Recently, contaminated feed was confirmed as a vehicle for PEDV infection of naïve piglets. according to Scott Dee of Pipestone Veterinary Services and co-authors there and at South Dakota State University.

Their research, published in BMC Veterinary Research, provides in vivo data supporting the ability of a liquid antimicrobial product to reduce this risk, they report.

Sal CURB® (Kemin Industries, Des Moines, IA, USA) is an FDA-approved liquid antimicrobial used to control Salmonella contamination in poultry and swine diets. To test its effect against PEDV, Sal CURB-treated feed was spiked with a stock isolate of PEDV (Ct = 25.22), which PEDV-naïve piglets were allowed to ingest via natural feeding behaviour (ad libitum) for a 14-day period.

For the purpose of a positive control, a separate group of piglets was allowed to ingest non-treated (Sal CURB-free) feed also spiked with stock PEDV (Ct = 25.22). A negative control group received PEDV-free feed.

Clinical signs of PEDV infection (vomiting and diarrhoea) and viral shedding in faeces were observed in the positive control group two to three days post-consumption of non-treated feed. In contrast, no evidence of infection was observed in pigs fed Sal CURB-treated feed or in the negative controls throughout the 14-day study period.

In addition, the Sal CURB-treated feed samples had higher (p< 0.0001) mean PEDV Ct values than samples from the positive control group.

These data provide proof of concept that feed treated with Sal CURB can serve as a means to reduce the risk of PEDV infection through contaminated feed, concluded Dee and co-authors.

Furthermore, they add, the results from the positive control group provide additional proof of concept regarding the ability of contaminated feed to serve as a risk factor for PEDV infection of naïve piglets.

Reference

Dee S., C. Neill, T. Clement, J. Christopher-Hennings and E. Nelson 2014. An evaluation of a liquid antimicrobial (Sal CURB®) for reducing the risk of porcine epidemic diarrhea virus infection of naïve pigs during consumption of contaminated feed. BMC Veterinary Research. 10:220. doi:10.1186/s12917-014-0220-9

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