Vaccination with Ingelvac PRRSFLEX® EU in Four Week Old Piglets Showed Efficacy During a Naturally Occurring Field Infection in Spain

Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) is one of the major pathogens in pigs that have a significant economic impact on the swine industry worldwide.
calendar icon 5 May 2017
clock icon 3 minute read

Vaccination against PRRSV has been demonstrated as an effective tool to control clinical signs related to infection. The aim of the present study was to evaluate field efficacy of a new PRRS genotype 1 modified live virus vaccine (Ingelvac PRRSFLEX® EU) in piglets at four weeks of age.


The study was conducted in a fattening farm in Spain with a history of PRRS infection. A total of 1,364 piglets were included in the study and assigned to two groups (vaccinated and non-vaccinated control animals). Piglets were followed for average daily weight gain as well as clinical signs, mortality and concomitant treatments.


Field infection with PRRSV occurred either before vaccination or shortly after. Peak viremia occurred around four weeks post vaccination. Vaccinated piglets showed a significant increase in average daily weight gain (ADWG) during peak of field infection (495 vs. 486 g/d).

In addition, the group of vaccinated piglets showed a significantly reduced mortality rate (4.9 vs 6.1%) and frequency of concomitant treatments (18.6 vs. 23.0 %), respectively. Furthermore, the proportion of pigs showing any abnormal clinical sign at least once at any of the examination time points was significantly lower in vaccinated pigs than in control pigs (4.2 vs. 8.3 %), with special emphasis on respiratory signs that were significantly reduced in vaccinated piglets as well (2.3 vs 4.7%).


This study established that protective immunity was induced in vaccinated pigs as early as 4 weeks after vaccination in the face of an ongoing field infection. In the face of PRRS viremia a clear beneficial impact on clinical and productive parameters was measured. Vaccination improved ADWG, and significantly reduced:

  • Mortality
  • Clinical signs
  • Respiratory signs
  • Skin alterations
  • Concomitant treatments

The importance of stabilizing the breeding herd to reduce the vertical transmission of PRRS to piglets is critical to the long term disease control.

G. Cano , M. Oliveira Cavalcanti, F.-X. Orveillon, J. Kroll, O. Gomez-Duran, A. Morillo, C. Kraft

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