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SDSU & Boehringer Team up against ETEC

by 5m Editor
29 July 2011, at 3:56pm

US - South Dakota State University (SDSU) and Boehringer Ingelheim have teamed up to fight enterotoxic E. coli (ETEC).

South Dakota State University is partnering with animal health leader Boehringer Ingelheim Vetmedica, Inc. to develop a new technology to protect pigs against a deadly form of E. coli.

SDSU filed a patent application before publishing its research findings on the technology, developed by assistant professor Weiping Zhang and professor David Francis in SDSU's Veterinary and Biomedical Sciences Department. Their work focused on a group of E. coli bacteria called enterotoxigenic Escherichia coli, or ETEC. ETEC bacteria produce toxins called enterotoxins that affect the tissues lining the intestine and cause vomiting and diarrhoea.

Currently, there are no preventative solutions offered by the major veterinary biological companies to combat ETEC. Denichiro Otsuga, director of SDSU's Technology Transfer Office, or TTO, saw a commercialisation opportunity in the SDSU invention to provide the solution to the unanswered market need. However, in order for the pork producers to take advantage of the SDSU invention and reduce their losses to ETEC, SDSU needed an industrial partner to help commercialise the technology.

Dr Otsuga said: "True to its land-grant mission, SDSU provides solutions to problems people face in the region, often through research activities but also by partnering with companies. The partnership between SDSU and Boehringer Ingelheim Vetmedica already has produced a product that benefits producers and pigs. SDSU and the University of Minnesota collaborated years ago in developing a patented vaccine for PRRS, or porcine reproductive and respiratory syndrome, that has been licensed to Boehringer Ingelheim Vetmedica Inc. and sold as a vaccine to prevent the death of piglets."

That long-standing relationship with Boehringer Ingelheim Vetmedica made SDSU look to the company for a possible partner on development of the latest SDSU invention to protect the health of swine herds and create value to the producers.

SDSU researchers' innovation is that they altered the toxin genes to make the bacterium produce a non-poisonous 'toxoid', then genetically fused the genes of two modified toxins to enhance their immune reaction. The bacterium producing the resulting 'fusion protein' plus other important products could be used to develop a vaccine to fight against the ETEC bacteria.

Dr Otsuga explained: "Once commercialised, the innovation from SDSU could be made available as a product, a vaccine, to protect weaning pigs from E. coli infections. When such a vaccine becomes available, it would add value to the swine industry, including South Dakota producers. The technology also has possible applications in human health, for which Dr Zhang is pursuing and developing a patent position in collaboration with the TTO."

SDSU's Technology Transfer Office works with SDSU scientists to protect the intellectual property they develop through their research. The office also works with private industry to bring those SDSU discoveries out of the laboratory and into the marketplace where they can provide practical solutions to the problems people face.

Besides causing diarrhoeal illness in farm animals such as pigs, ETEC strains are a major cause of bacterial-caused diarrhoea in human populations in the developing world. ETEC is the chief cause of traveller's diarrhoea. The World Health Organization estimates that ETEC causes approximately 210 million cases of illness in humans and 380,000 deaths, mostly in children in developing countries.

The research is one of the ongoing projects in SDSU's Center for Infectious Disease Research and Vaccinology, which looks for new ways to diagnose and treat infectious disease in humans and domestic animals.