Novartis Launches Strenzen for Treatment of Respiratory, Enteric Diseases in Pigs

SWITZERLAND - Novartis Animal Health (NAH) has announced the launch of Strenzen® (amoxicillin, clavulanic acid), an oral water medication for pigs containing a combination of amoxicillin trihydrate (500mg/g) and potassium clavulanate (125mg/g) in ratio of 4:1.
calendar icon 14 April 2014
clock icon 5 minute read

Strenzen is indicated for the treatment of gastrointestinal infections caused by Escherichia coli, Clostridium perfringens and Salmonella Typhimurium, and for respiratory tract infections caused by Actinobacillus pleuropneumoniae, Pasteurella multocida and Streptococcus suis, making it ideally suited for the treatment of postweaning infections in pigs. Strenzen is first launched in Denmark, France, Germany, Italy, the Netherlands, Portugal, Spain and UK.

The combination of amoxicillin and clavulanic acid broadens the performance of amoxicillin1,2, especially against resistant strains of bacteria capable of producing β- lactamase enzymes. Certain bacteria are able to produce β-lactamase enzymes as a protection mechanism, making the amoxicillin molecule ineffective against them. The clavulanic acid in Strenzen binds to the molecules of the β-lactamase enzyme, ensuring the amoxicillin remains unaffected and free to attack bacteria.

"Weaning is a stressful event for piglets and there are several opportunistic diseases that can impact them during this period," said Professor Dominiek Maes, DVM, MSc, MS, PhD, Dipl. ECVPH, Dipl. ECPHM, from the Porcine Health Management Unit of the Ghent University, Belgium. "The challenge with E. coli and S. suis infections is that in many countries there are currently no commercial vaccines available with proper efficacy. I believe Strenzen can indeed be very helpful in managing those infections which are so prevalent after weaning."

Strenzen is rapidly excreted, leading to a withdrawal period of just one day, which in turn maximizes production flexibility for pig producers in the European launch countries. In addition, the water-soluble formulation of Strenzen ensures that treated pigs get a therapeutic dose even when they stop eating, making it an ideal treatment for sick pigs with compromised appetites.

Recent field trials on infected farms in Spain and the Czech Republic demonstrate that Strenzen-treated pigs give better production performance, better economic returns and require less medical intervention3,4,5. The reduction of the overall amount of antibiotics needed to treat severe post-weaning infections not only saves producers the costs of the labor and the medication, but is also important in regard to the development of resistance in bacteria.

"With the launch of Strenzen, Novartis Animal Health demonstrates its commitment to continually broadening our product portfolio to address the specific needs of farmers and food producers," said Dr Ulrich Klein, Global Technical Services Manager, Novartis Animal Health. "Strenzen has the ideal spectrum for the treatment of post-weaning infections, delivering better productivity results than current therapies for those infections."


1 J. Dallow (2013): MIC determination of the VetPath III collection of veterinary bacterial pathogens in Europe. Quotient Bio Analytical Sciences – Internal Report.
2 Masarikova M. & A.Cizek (2011): In vitro susceptibility of Czech porcine isolates of C. perfringens Type A cpb2+ to amoxicillin and amoxicillin/clavulanic acid. Trial report.
3 Morales J & C.Pineiro (2012). Comparative study of treatment for post-weaning diarrhoea due to Escherichia coli in piglets with Amoxicillin plus Clavulanic acid via drinking water versus other antibiotic products. Internal report. December 2012.
4 Vinduška J.& E.Šmídová (2012). Comparison of treatment efficiency of Strenzen (amoxicillin and clavulanic acid) with amoxicillin and colistin for the prevention and control of E. coli post-weaning diarrhoea (enteropathogenic strains F4, F18, toxin producing strains) and S. suis infection.
5 Morales J & C.Pineiro (2013). Comparative study of treatment for post-weaning diarrhoea due to Escherichia coli in piglets with amoxicillin plus clavulanic acid via drinking water versus other antibiotic products. Internal report June 2013.


This press release contains expressed or implied forward-looking statements, including statements that can be identified by terminology such as "continues to," "commitment," "committed," or similar expressions. Such forward-looking statements reflect the current views of the Group regarding future events, and involve known and unknown risks, uncertainties and other factors that may cause actual results to be materially different from any future results expressed or implied by such statements. These expectations could be affected by, among other things, risks and factors referred to in the Risk Factors section of Novartis AG's current Form 20-F on file with the US Securities and Exchange Commission. Novartis is providing the information in this press release as of this date and does not undertake any obligation to update it in the future.

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