Scientific foundation explains efficacy of Excede® for Swine against SRD pathogens

A robust body of research explains the efficacy of Excede® for Swine (ceftiofur crystalline free acid) against four of the bacterial pathogens associated with swine respiratory disease (SRD).
calendar icon 20 July 2021
clock icon 6 minute read
Eva Jablonski, DVM, senior technical services veterinarian for Zoetis
Eva Jablonski, DVM, senior technical services veterinarian for Zoetis
Note: 0.2 ug/mL is the concentration that is above MICs for nearly 100% of target respiratory pathogens isolated and tested over the years.
Note: 0.2 ug/mL is the concentration that is above MICs for nearly 100% of target respiratory pathogens isolated and tested over the years.
Note: Percentages with different superscripts differ significantly (P = 0.01)
Note: Percentages with different superscripts differ significantly (P = 0.01)
References
References
Hibbard B, et al.
(2004) Pharmacokinetics of Ceftiofur Crystalline Free Acid in Swine.. Proceedings of the 18th IPVS Congress, Hamburg, Germany Volume 2.
Ibid
Sweeney M, et al.
(2011 to 2015) Antimicrobial susceptibility of Actinobacillus pleuropneumoniae, Pasteurella multocida, Streptococcus suis, and Bordetella bronchiseptica isolated from pigs in the United States and Canada. J Swine Health Prod. 2017 25(3):106-120
Schionning S, et al.
(August 1994) Determination of tissue concentrations of desfuroylceftiofur in pigs after intramuscular injection of Excenel Sterile Powder.. 6th EAVPT Congress
Sweeney M, et al.
(2011 to 2015) Antimicrobial susceptibility of Actinobacillus pleuropneumoniae, Pasteurella multocida, Streptococcus suis, and Bordetella bronchiseptica isolated from pigs in the United States and Canada,
Leman AMR Roundtable Proceedings,
(2019) Mapping a course for responsible, effective antimicrobial use in swine. pages 5-7
Blondeau J, et al.
(2019) Mutant prevention and minimum inhibitory concentration drug values for enrofloxacin, ceftiofur, florfenicol, tilmicosin and tulathromycin tested against swine pathogens Actinobacillus pleuropneumoniae, Pasteurella multocida and Streptococcus suis.. PLOS ONE Volume 14(1)
Ibid
Zoetis LLC
Data on file, Study Report No. ORPORK 2030
Zoetis LLC
Data on file, Study Report No. 1123C-60-08-315
Ibid

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