PRRSV Type 1 Can Induce Aggravation of Infection with a Mild Actinobacillus Serotype 2 Strain

Porcine reproductive and respiratory syndrome virus (PRRSV) predisposes pigs to the aggravation of an App infection.
calendar icon 18 September 2015
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Key Messages

  • The presence of PRRSV significantly increased the cases of pneumonia compared to App infection alone (Group 1: 6/10 × pneumonia; group 2: 1/10 × pneumonia, group 3: 0/6 × pneumonia).
  • PRRSV predisposes for an aggravation of an App infection.

Article Brief

An experimental co-infection study with PRRSV genotype 1, subtype 1 (Lelystad strain) followed by a App serotype 2 infection was performed. Actinobacillus pleuropneumoniae (App) serotype 2 is the most frequently diagnosed serotype in western European swine farms.

Three groups of 10 pigs were used to inoculate:

  • Group 1: PRRSV/App 2
  • Group 2: PBS/App2
  • Group 3: PBS/PBS).

Pigs were clinically monitored for seven days following App infection.

The presence of PRRSV significantly increased the cases of pneumonia compared to App infection alone (Group 1: 6/10 × pneumonia; Group 2: 1/10 × pneumonia, Group 3: 0/6 × pneumonia).

All PRRSV-infected pigs developed fever four hours after App infection, whereas pigs infected only with App did not show increased body temperature. This could be due to reported increase in CD14 expressing cells in the lungs following PRRSV infections, and might explain a higher susceptibility to lung infections by Gram-negative bacteria in PRRSV-infected pigs.

From this results, it is concluded that PRRSV predisposes for an aggravation of an App infection.

Reference

N. Stockhofe-Zurwieden, H. Wisselink, J. Post and J.M.J. Rebel. 2013. PRRSV type 1 can induce aggravation of infection with a mild virulent Actinobacillus serotype 2 strain. International PRRS Symposium.

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September 2015

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