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    Is the intradermal vaccination against PRRS as efficacious as the intramuscular one??

    The advantages of the intradermal (ID) administration by a needle-less device are that it is less invasive, painless, safe, quick and easy. Furthermore, the ID administration could induce a stronger cellular response compared to the intramuscular (IM) due to the delivery through the ID route could induce T cell polarization favoring the induction of interferon gamma secreting cells (IFN-γ-SC). In PRRSV infection, interleukin 10 (IL-10) levels are reportedly associated with severity of clinical disease (van Reeth and Nauwynck, 2000) and can delay the immune response. Higher IFN-γ-SC in ID vaccinated pigs could be due to the lower IL-10 levels.
    calendar icon 25 November 2020
    clock icon 4 minute read
    By: Lidia de Lucas | Joel Miranda
    Table 1: Groups distribution during the entire study
    Table 1: Groups distribution during the entire study
    Figure 2. Quantification of IL-10 in the supernatant of stimulated PBMC with the vaccine strain following vaccination.
    Figure 2. Quantification of IL-10 in the supernatant of stimulated PBMC with the vaccine strain following vaccination.
    Figure 3. Evaluation of PRRSV-specific IFN- γ -secreting cells (SC) after stimulation with (A) homologous virus (vaccine virus), (B) heterologous PRRSV1 (AN06EU4204) and (C) heterologous HP-PRRSV2 (FDT10US23). Values are expressed as the mean±SEM.
    Figure 3. Evaluation of PRRSV-specific IFN- γ -secreting cells (SC) after stimulation with (A) homologous virus (vaccine virus), (B) heterologous PRRSV1 (AN06EU4204) and (C) heterologous HP-PRRSV2 (FDT10US23). Values are expressed as the mean±SEM.
    Figure 4. Microscopic lung lesions following challenge of the (A) non vaccinated/challenged, (B) IM vaccinated pigs, (C) ID vaccinated pigs and (D) non vaccinated/non challenge pigs. H&E staining. Bar =100 μm.
    Figure 4. Microscopic lung lesions following challenge of the (A) non vaccinated/challenged, (B) IM vaccinated pigs, (C) ID vaccinated pigs and (D) non vaccinated/non challenge pigs. H&E staining. Bar =100 μm.
    Figure 5. Macroscopic lung lesions following challenge at 7 DPC of the (A) non vaccinated/challenged, (B) IM vaccinated pigs, (C) ID vaccinated pigs and (D) non vaccinated/non challenge pigs.
    Figure 5. Macroscopic lung lesions following challenge at 7 DPC of the (A) non vaccinated/challenged, (B) IM vaccinated pigs, (C) ID vaccinated pigs and (D) non vaccinated/non challenge pigs.
    References
    References
    van Reeth, K., Nauwynck, H.,
    (2000) Proinflammatory cytokines and viral respiratory disease in pigs.. Vet. Res. 31, 187–213.
    Madapong, A et al.,
    (2020) Immune response and protective efficacy of intramuscular and intradermal vaccination with porcine reproductive and respiratory syndrome virus 1 (PRRSV-1) modified live vaccine against highly pathogenic PRRSV-2 (HP-PRRSV-2) challenge, either alone or in combination with of PRRSV-1,. Veterinary Microbiology, Volume 244.

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    Lidia de Lucas

    Hipra
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    Joel Miranda

    HIPRA, Amer (Girona), Spain
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