Pharmacology explains efficacy of Draxxin for SRD

Pharmacologic research demonstrating how Draxxin (tulathromycin) injection behaves in the pig explains why this antimicrobial remains a valuable treatment for swine respiratory disease (SRD).
calendar icon 17 August 2021
clock icon 9 minute read
Ashley Johnson, DVM, Zoetis
Ashley Johnson, DVM, Zoetis
References
References
Overview of respiratory diseases of pigs. Merck Veterinary Manual
Benchaoui HA, et al.
(2004) Pharmacokinetics and lung tissue concentrations of tulathromycin in swine.. J Vet Pharmacol Ther. 27:203-210.
Ibid
Fischer CD, et al.
(2013) Direct and Indirect Anti-Inflammatory Effects of Tulathromycin in Bovine Macrophages: Inhibition of CXCL-8 Secretion, Induction of Apoptosis, and Promotion of Efferocytosis.. Antimicrob Agents Chemother. March;57(3): 1385-1393
Siegel TW, et al.
(2004) Cellular uptake of the triamilide tulathromycin by bovine and porcine phagocytic cells in vitro.. J Anim Sci 82(1):186.
Fischer CD, et al.
Direct and Indirect Anti-Inflammatory Effects of Tulathromycin in Bovine Macrophages
McKelvie J, et al.
(2005) Comparative efficacy of tulathromycin injectable solution (Draxxin) for the treatment of experimentally induced respiratory infections in swine.. Am Assoc Swine Vet annual meeting, Toronto
Mycoplasmal pneumonia (enzootic pneumonia). Iowa State Unimversity
Benchaoui HA, et al.
Pharmacokinetics and lung tissue concentrations
Study Report No. 1121R-60-07-292, Zoetis LLC
Study Report No. 1121C-60-04-230, Zoetis LLC
Study Report No. 1121C-60-03-209, Zoetis LLC
King D, et al
(2013) Effects of Draxxin at weaning in pigs on control of swine respiratory disease including “low” level of PRRS involvement and subsequent performance of pigs.. Am Assoc Swine Vet annual meeting, San Diego
King D, et al.
(2014) Effects of Draxxin at weaning for control of swine respiratory disease in pigs experiencing a natural outbreak.. Am Assoc Swine Vet annual meeting, Dallas
Sievers C, et al.
(2014) Effect of tulathromycin or ceftiofur free acid on post-weaning performance and economic return in porcine reproductive and respiratory syndrome virus infected pigs.. Am Assoc Swine Vet annual meeting, Dallas.

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