Vaccination Influences the Evolution of Classical Swine Fever Virus

A study from China indicates suggests that excessive use of attenuated vaccines against classical swine fever should be avoided.
calendar icon 4 June 2014
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Classical swine fever is a serious, economically damaging disease caused by classical swine fever virus (CSFV), according to Wei Ji and co-authors of a paper in the journal, Infection, Genetics and Evolution.

The researchers explain that the CSFV is composed of two clades, according to phylogenetic estimates. Attenuated live vaccine such as HCLV, has been widely used to protect pigs from CSFV, but the influence of vaccination on the evolution of CSFV has not been studied.

The group conducted a systemic analysis of the impact of vaccination on the evolution of CSFV by comparing vaccine-related and non-vaccine-related CSFV groups.

They found that vaccination may affect strain diversity and immune escape through recombination and point mutation. Futhermore, they found that vaccination may influence the population dynamics, evolutionary rate and adaptive evolution of classical swine fever virus.

Their results suggest that the vaccination might also change host adaptation through influencing codon usage of the virus in swine.

Ji and co-authors concluded that excessive use of CSFV attenuated vaccines should be avoided.


Ji W., D. Niu, H. Si, N. Ding and C. He. 2014. Vaccination influences the evolution of classical swine fever virus. Infect. Genet. Evol. 25:69-77. doi: 10.1016/j.meegid.2014.04.008.

Further Reading

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June 2014

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