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7.1.2 Why is Enterisol® Ileitis a live vaccine?

A successful vaccine against intracellular bacteria has to induce cell-mediated immunity as well as the production of local antibodies. In general only a very low percentage of orally ingested antigens are absorbed by the enterocytes. The incorporation of Lawsonia intracellularis into the cell is an active process initiated by the bacte­rium. Accordingly an inactivated vaccine would provide the intestine with insufficient immunogenic antigen (Haesebrouck et al. 2004).

Only attenuated live vaccines induce sufficient cell-mediated protection in the intestinal cells. Therefore, a vaccine against Lawsonia intracellularis needs to be a live vaccine.

Picture 7.1d
As an alternative to the administration via the drinking water, the vaccine can be applied via a drench.

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